フィセチン 化學(xué)特性,用途語,生産方法
外観
うすい黃色～暗緑褐色、結(jié)晶性粉末～粉末
定義
本品は、次の化學(xué)式で表される有機(jī)化合物である。
解説
フィセチン，黃色の針狀晶．分解點(diǎn)348 ℃．λmax 248，319，362 nm．エタノール，酢酸エチル，アセトンに可溶，エーテル，石油エーテル，ベンゼン，クロロホルムに微溶，冷水に不溶．エタノール溶液は種々の金屬，希土類の蛍光定量に用いられる．LD50 180 mg/kg(マウス，靜注)．
森北出版「化學(xué)辭典（第2版）
化粧品の成分用途
皮膚コンディショニング剤、著色剤
製造
フラボノール類の一つ．西インド産のウルシ科Rhus cotinusやサイカチGleditsia japonica Miq.の心材に含まれるフィセチン．
説明
Fisetin, a well-known plant flavonol from natural flavonoid group, is found in traditional medicines, plants, vegetables, fruits. Fisetin also has anti-oxidant, anti-inflammatory, anti-tumor effects
[1].
化學(xué)的特性
OCHRE POWDER
使用
Fisetin is used in biological studies as spleen tyrosine kinase inhibitors for autoimmune inflammation disease. This compound has neuroprotective properties.
主な応用
Fisetin is primarily used in laboratory bioactivity studies as an analytical standard for qualitative and quantitative analyses of Fisetin, and as a dietary supplement, and sells well for its potential anti-aging and cognitive enhancing effects. Because of its potent antioxidant and anti-inflammatory properties, it has been shown to have varying degrees of inhibitory effects on a wide range of diseases (e.g., cancer, Alzheimer's disease, anti-aging cells, and diabetes), and has been extensively studied in terms of its pharmacological effects in vitro and in vivo.
利點(diǎn)
Fisetin is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection.It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.
生物學(xué)の機(jī)能
Fisetin shows great potential as a senolytic agent and has broad potential clinical applications, but currently only limited human data are available. [1]
一般的な説明
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
作用機(jī)序
Fisetin has multi-pathway and multi-target properties. Studies have shown that Fisetin can induce p53 activation and cause cell cycle arrest at various checkpoints by activating caspase-8, caspase-9, caspase-3 and inhibiting Bcl-2, leading to apoptosis, and inhibition of NF-κB and ERK1/2 activities, thus inhibiting the survival and growth of tumour cells. In addition, by inhibiting the PI3K/Akt pathway, it also blocks the mTOR pathway and controls feedback loops, as well as preventing oxidative stress, inflammatory responses, and cytotoxicity by modulating the activity of the PI3K/Akt, Nrf2, NF-κB, protein kinase C, and MAPK pathways.
抗がん研究
Fisetin is a plant polyphenol from the flavonoid group. It occurs in fruits and vegetablesincluding persimmons, strawberries, onions, cucumbers, and apples. It is anantioxidant, exerts anticarcinogenic effects in HCT-116 (human colon carcinoma)cells, and modulates protein kinase and lipid kinase pathways (Wang et al. 2012).Fisetin alter signaling pathway like MAPK, NF-κB, activators of transcription(JAK/STAT), Janus kinase/signal transducers, phosphoinositide-3-kinase-proteinkinase (PI3K/Akt), Wnt, and mammalian target of rapamycin (mTOR), therebyleading to cell cycle arrest in HL-60 cells (human acute promyelocytic leukemiacells) (Singh et al. 2016b). Thus, it exhibits inhibitory effects on adhesion, migration,invasion, and multidrug resistance (Suh et al. 2009).
Source
Fisetin is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.
參考文獻(xiàn)
[1]
KIM T W. Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer.[J]. International Journal of Molecular Sciences, 2023, 24 10. DOI:10.3390/ijms24109076.
フィセチン 上流と下流の製品情報
原材料
準(zhǔn)備製品