メマンチン塩酸塩 化學(xué)特性,用途語(yǔ),生産方法
外観
白色～ほとんど白色、結(jié)晶～粉末白色～ほとんど白色, 結(jié)晶～粉末
溶解性
ぎ酸及びエタノール(99.5)に溶けやすく、水にやや溶けやすい。
用途
グルタミン酸作動(dòng)性NMDA 受
容體のアンタゴニストです。イオンチャネル
サイトに結(jié)合しドーパミンの放出を刺激する
作用を示します。
用途
グルタミン酸作動(dòng)性NMDA受 容體のアンタゴニストです。イオンチャネル サイトに結(jié)合しドーパミンの放出を刺激する 作用を示します。
効能
認(rèn)知癥治療薬, NMDA受容體拮抗薬
商品名
メマリー (第一三共); メマリー (第一三共)
説明
Memantine, a NMDA receptor antagonist, was
co-developed by Forest Laboratories with Merz
Pharmaceuticals and marketed under the trade name
Namenda for the treatment of Alzheimer’s disease in the US
after its approval in October, 2003. This drug has been
available in many European and Asian markets before
getting approval in the US.
化學(xué)的特性
Crystalline Solid
主な応用
Memantine HCl has been used:
- as a media
supplement to serve as a control to study the neuroprotective effects of
erythropoietin in N-methyl-D-aspartate receptor-induced toxicity.
- to intraperitoneally inject experimental animal to study its effect on traumatic injury.
- as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration.
使用
Used as an antiparkinsonian and antispasmodic
定義
ChEBI: A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
一般的な説明
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Memantine Hydrochloride is a drug used for treating the Alzheimer′s disease by means of reducing abnormal activity in the brain. It can help patients suffering from dementia as it assists them to think more clearly and perform their chores with ease.
副作用
Serious side effects:
Allergic reaction. Symptoms can include:
swelling of your tongue, lips, or face; shortness of breath; skin rash; hives
Hepatitis (inflammation of the liver). Symptoms can include:
yellowing of your skin or the whites of your eyes.
Pancreatitis (inflammation of the pancreas). Symptoms can include:
severe nausea; severe abdominal pain.
Change in mental health. Symptoms can include:
hallucinations; thoughts of suicide.
Congestive heart failure. Symptoms can include:
shortness of breath; swelling in your feet and ankles.
メマンチン塩酸塩 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品