Clevidipine butyrate
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Clevidipine butyrate ??
- ???
- 128-130°C
- ?? ?
- 539.7±50.0 °C(Predicted)
- ??
- 1.289
- ???
- 280℃
- ?? ??
- Keep in dark place,Inert atmosphere,2-8°C
- ???
- ?? ???
- ???
- ≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic
- ?? ?? (pKa)
- 2.45±0.70(Predicted)
- ??? ??
- powder to crystal
- ??
- ???? ?? ???
- InChI
- 1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
- InChIKey
- KPBZROQVTHLCDU-UHFFFAOYSA-N
- SMILES
- Clc1c(cccc1C2C(=C(NC(=C2C(=O)OC)C)C)C(=O)OCOC(=O)CCC)Cl
- CAS ??????
- 167221-71-8
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| WGK ?? | WGK 3 | ||
| HS ?? | 29339900 | ||
| ???? ??? | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Repr. 2 |
Clevidipine butyrate C??? ??, ??, ??
??
Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine (DHP) class of CCB. It is indicated as an intravenous treatment for the acute management of hypertension when oral therapy is not feasible or not desirable. Clevidipine is the second intravenous CCB to be marketed behind nicardipine for this indication. Both agents are primarily used for urgent treatment of hypertension in cardiac surgical setting, intensive care units, and emergency departments. Other intravenous agents currently on the market for this indication include sodium nitroprusside, nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect on the myocardial contractility and venous capacitance. It has a rapid onset and offset of action and a very short plasma half-life, which allows for titration of the drug to achieve precise BP control.clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.
??? ??
White to Off-White Solid??
Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。???
Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.Clevidipine butyrate ?? ?? ? ???
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Clevidipine butyrate ?? ??
???( 317)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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Clevidipine butyrate ?? ??:
FLURBI??FEN 3,5-?????????
Losartan potassium
3-((butyryloxy)Methyl) 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethylpyridine-3,5-dicarboxylate
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester
1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
Periplocoside
FLURBIPROFEN AXETIL
Daptomycin
Esomeprazole sodium
Urapidil hydrochloride
Prostaglandin E1
Dasatinib
Levetiracetam
Erlotinib hydrochloride
Pregabalin
Nimodipine
Clevidipine