???
??? ??
???
158-1600C
??
D +24.5° (chloroform)
?? ?
416.25°C (rough estimate)
??
1.1236 (rough estimate)
???
1.5000 (estimate)
?? ??
room temp
???
DMSO: ???20mg/mL, ??
??? ??
??
??
???? ????
?? ??
[α]/D +17 to +24°, c = 1 in chloroform-d
???
272.4ug/L(25℃)
?? ??
???(???)
InChI
InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3
InChIKey
UJVLDDZCTMKXJK-MUWITHSMNA-N
SMILES
[C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r|
LogP
2.54 at 25℃
CAS ??????
976-71-6
NIST
Canrenone(976-71-6)
??
?? ? ?? ??
?? ? ???? ?? (GHS)
??? ??
Xn,N
?? ???? ??
40-51/53
?????
36/37-61
????(UN No.)
UN 3077 9 / PGIII
WGK ??
3
?? ??
9
HS ??
29329990
???? ???
11 - Combustible Solids
Hazard Classifications
Aquatic Chronic 2
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H351 ?? ??? ??? ??? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??)
??? ??
?? 2
??
P201, P202, P281, P308+P313, P405,P501
H411 ??? ??? ?? ????? ???
?? ????? ?? - ??
?? 2
??????:
P280 ????/???/???/?????? ?????.
??? C??? ??, ??, ??
??? ??
Pale yellow to pale Green Solid
??
Aldosterone antagonist. Diuretic
World Health Organization (WHO)
Canrenone, which has aldosterone antagonist activity, is a major
metabolite of spironolactone and the major metabolite of potassium canrenoate.
See WHO comments for potassium canrenoate and spironolactone.
???? ??
Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ).
??? ?? ?? ? ???
???
?? ??
??? ?? ??
???( 261)?? ??
Canada 3
China 208
France 1
Germany 3
India 8
Spain 2
United Kingdom 9
United States 26
Venezuela 1
Global 261
