ChemicalBook >?? ???? >API>??? ??>? ??? ?>Ziprasidone hydrochloride monohydrate

Ziprasidone hydrochloride monohydrate

Ziprasidone hydrochloride monohydrate ??? ???

?? ??:: 138982-67-9

???:: Ziprasidone hydrochloride monohydrate

???(??):: ZIPRASIDONE HCL;CP-88059-1;5-[2-[4-(1;Ziprasidong Hcl;Ziprasidone HCl hydrate;ZIPRASIDONE INTERMEDIATE;Ziracizidine Hydrochloride;ZIPRASIDONE HCL MONOHYDRATE;ZIPRASITONE HCl MONOHYDRATE;Geodon Hydrochloride Hydrate

CBNumber:: CB0166832

???:: C21H24Cl2N4O2S

??? ??:: 467.41

MOL ??:: 138982-67-9.mol

?? ?? 381

Ziprasidone hydrochloride monohydrate ??

???: 300°C

?? ??: 2-8°C

???: DMSO: >10mg/mL

??? ??: ??

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Merck: 14,10171

BCS Class: 2

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InChI: 1S/C21H21ClN4OS.ClH.H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H;1H2

InChIKey: ZCBZSCBNOOIHFP-UHFFFAOYSA-N

SMILES: C(N1CCN(C2=NSC3=CC=CC=C23)CC1)CC1=C(C=C2NC(=O)CC2=C1)Cl.Cl.O

CAS ??????: 138982-67-9(CAS DataBase Reference)

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?? ? ???? ?? (GHS)

?????	24/25
????(UN No.)	UN1230 - class 3 - PG 2 - Methanol, solution
WGK ??	3
RTECS ??	NM3241200
HS ??	38220010
???? ???	11 - Combustible Solids
Hazard Classifications	Skin Sens. 1 STOT RE 2 Oral

????(GHS):

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Warning

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??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H317	????? ?? ??? ??? ? ??	?? ??? ??	?? 1	??		P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H373	??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ??	?? ???? ?? - ?? ??	?? 2	??		P260, P314, P501

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P260	??·?·??·???·??·...·????? ???? ???.
P280	????/???/???/?????? ?????.

Ziprasidone hydrochloride monohydrate C??? ??, ??, ??

??? ??

Pale Tan Powder

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Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.

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ChEBI: The hydrochloride hydrate salt of ziprasidone.

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Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT 2A receptors with a 5-HT 2A /D 2 affinity ratio greater than any other clinically available atypical antipsychotics (pK i values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT 2A , 5-HT 2C , 5-HT 1D , 5-HT 1A , D 2 , D 3 , α 1 , D 4 , H 1 and D 1 receptors respectively).

Ziprasidone hydrochloride monohydrate ?? ?? ? ???

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Serotonin hydrochloride Benzoisothiazole ???? ?? ???????? p-??? 3-(1-?????)-1,2-??????? 6-Chloro-5-(2-chloroethyl)oxindole

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Ziprasidone hydrochloride monohydrate ?? ??

???( 381)?? ??

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Ziprasidone hydrochloride monohydrate ?? ??:

Ziprasidone 3-(1-Piperazinyl)-1,2-benzisothiazole Zirconium hydroxide 3-Oxo Ziprasidone (Ziprasidone Impurity B) 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE 3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole Hydroxy Ziprasidone Ziprasidone N-Oxide 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl-4-chloro-2-nitrophenol 6-chloro-5-[2-[4-(2-methylsulfanylbenzenecarboximidoyl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one 5,5'-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6'-dichloro-3-hydroxy-3,3'-biindoline-2,2'-dione 1,2-Benzisothiazole, 3-(1-piperazinyl)-, 1-oxide 3-(1,2-Benzisothiazolyl) Ziprasidone (Ziprasidone Impurity E) Ziprasidone Amino Acid (Ziprasidone Impurity C) 3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethenyl]-1-piperazinyl]-1,2-benzisothiazole 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-4-chloro-2-nitro-benzeneacetic Acid 1,2-Benzisothiazole, 3-(1-piperazinyl)-, 1,1-dioxide Ziprasidone Hydrochloride

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