N,N-???????-4-??
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N,N-???????-4-?? ??
- ?? ?
- 187°C
- ??
- 1.09g/ml
- ???
- 187°C
- ???
- 1.4760
- ?? ??
- under inert gas (nitrogen or Argon) at 2–8 °C
- ??? ??
- ??
- ?? ?? (pKa)
- 10.10±0.10(Predicted)
- ??
- Clear, colourless
- BRN
- 1190
- InChI
- InChI=1S/C7H16N2/c1-9(2)7-3-5-8-6-4-7/h7-8H,3-6H2,1-2H3
- InChIKey
- YFJAIURZMRJPDB-UHFFFAOYSA-N
- SMILES
- N1CCC(N(C)C)CC1
- CAS ??????
- 50533-97-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi,Xn | ||
|---|---|---|---|
| ?? ???? ?? | 10-34-22 | ||
| ????? | 26-36/37/39-45 | ||
| ????(UN No.) | 2734 | ||
| WGK ?? | WGK 3 | ||
| ?? ?? ?? | Irritant | ||
| ?? ?? | 8 | ||
| ???? | III | ||
| HS ?? | 2933399990 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 |
N,N-???????-4-?? C??? ??, ??, ??
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4-(Dimethylamino)piperidine is having molecular features associated with polyamine modulation of N-methyl-D-aspartate receptors. It is utilized as a mechanism for reducing the effects of alcohol dependence.Synthesis
1-(tert-Butoxycarbonyl)-4-piperidone (998 mg, 4.75 mmol) in methanol (15 mL) was treated with dimethylamine hydrochloride (800 mg, 9.8 mmol) and sodium cyanoborohydride (270 mg, 4.3 mmol) at rt. After 4 days, concentrated HCl (10 mL) was added and the reaction was reduced in vacuo. The resulting residue was dissolved in H2O (30 mL) and treated with 2M NaOH solution to achieve a pH of 10. The aqueous solution was extracted with methylene chloride (3×20 mL) and the combined organics were dried over Na2SO4 and removed in vacuo. The resulting product is N,N-Dimethylpiperidin-4-amine (169 mg).
N,N-???????-4-?? ?? ?? ? ???
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N,N-???????-4-?? ?? ??
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