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?????????
????????? ??? ???
?? ??:
480-18-2
???:
?????????
???(??):
?????????
???:
Taxifolin
???(??):
DIHYDROQUERCETIN;(+)-TAXIFOLIN;distylin;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one;taxifoliol;Larch extract;2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroMan-4-one;Lavitol;(±)-Taxifolin;(2R,3R)-(+)-Taxifolin
CBNumber:
CB0402424
???:
C15H12O7
??? ??:
304.25
MOL ??:
480-18-2.mol
MSDS ??:
SDS

????????? ??

???
230-233°C (dec.)
?? ?
365.09°C (rough estimate)
??
1.3326 (rough estimate)
???
1.4790 (estimate)
?? ??
-20°C
???
DMSO(?? ???), ???(?? ???)
?? ?? (pKa)
7.39±0.60(Predicted)
??? ??
Solid
??
???? ?????
BRN
5299277
?? ??
?? ? ??
??? ?? ??
????
InChI
InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
InChIKey
CXQWRCVTCMQVQX-LSDHHAIUSA-N
SMILES
[C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP
0.950
CAS ??????
480-18-2(CAS DataBase Reference)
EPA
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (480-18-2)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
?? ???? ?? 22
????? 22-24/25
WGK ?? 3
RTECS ?? LK6920000
TSCA TSCA listed
?? ?? IRRITANT
HS ?? 29329990
???? ??? 11 - Combustible Solids
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
0
2 0

????????? C??? ??, ??, ??

??

Taxifolin, a chemical substance extracted from pine plants such as larch and Douglas fir. It belongs to the bioflavonoid pseudo-vitamin P, and its scientific name is dihydroquercetin. Japanese scholar Fukui first isolated it from the leaves of conifers (Chamaecyparis obtusa), and its biological activity was subsequently discovered and confirmed.

??? ??

Yellow Solid

??

An antioxidant flavenoid.

?? ??

Taxifolin is a flavonoid commonly found in onion, milk, French maritime pine bark and Douglas fir bark. It is also used in various commercial preparations like Legalon, Pycnogenol, and Venoruton. This review focuses on taxifolin’s biological activities and related molecular mechanisms. It showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The anti-cancer activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.

??

ChEBI: A taxifolin that has (2R,3R)-configuration.

?? ??

Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.

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