4-Amino-3,5-dichloroacetophenone
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4-Amino-3,5-dichloroacetophenone ??
- ???
- 162-166 °C(lit.)
- ?? ?
- 351.5±42.0 °C(Predicted)
- ??
- 1.2748 (rough estimate)
- ???
- 1.5500 (estimate)
- ?? ??
- Keep in dark place,Inert atmosphere,Room temperature
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- -1.72±0.10(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ?? ????? ????
- InChI
- InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
- InChIKey
- JLPKZJDZXIKSCP-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C
- CAS ??????
- 37148-48-4(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36-37/39 | ||
| WGK ?? | 3 | ||
| HS ?? | 29223990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
4-Amino-3,5-dichloroacetophenone C??? ??, ??, ??
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4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.??
4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.?? ??
4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.?? ??
4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.4-Amino-3,5-dichloroacetophenone ?? ?? ? ???
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4-Amino-3,5-dichloroacetophenone ?? ??
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