Reviparin sodium, a second-generation low molecular weight heparin produced from
porcine mucosal heparin, has been introduced for the prevention of deep vein thrombosis and
pulmonary embolism following surgery. It has sustained activity and increased bioavailability
over unfractioned heparin. More noticeably, reviparin shows a pronounced inhibitory effect,
both in vitro and in vivo , on smooth muscle cell proliferation which plays a predominant role in
restenosis following angioplasty. Indeed, a lower incidence of restenosis without major
bleeding complications has been reported for reviparin treated patients who successfully
underwent percutaneous transluminal coronary angioplasty.
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off-white powder
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Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.
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Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.
Purification Methods
Dissolve the salt in 0.1M NaCl (1g/100mL) and precipitate it by additing EtOH (150mL). [Wolfrom et al. J Org Chem 29 540 1946, Huggard Adv Carbohydr Chem 10 336-368 1955.]
