4-??????
|
|
4-?????? ??
- ???
- 76-79 °C(lit.)
- ?? ?
- 196 °C
- ??
- 1.1145 (rough estimate)
- ???
- 41.9Pa at 25℃
- ???
- 1.5242 (estimate)
- ???
- 88 °C
- ?? ??
- Sealed in dry,Room Temperature
- ???
- 40g/L
- ??? ??
- ?? ?? ??
- ?? ?? (pKa)
- pK1:1.90(+1) (25°C)
- ??
- ???? ?????
- ???
- 3.2 g/100ml (16.4 ºC)
- BRN
- 107712
- Henry's Law Constant
- 1.1×101 mol/(m3Pa) at 25℃, Abraham et al. (1994)
- ?? ??
- NIOSH: IDLH 25 mg/m3
- ???
- ????. ???, ????, ??? ???? ????.
- InChI
- 1S/C6H4N2/c7-5-6-1-3-8-4-2-6/h1-4H
- InChIKey
- GPHQHTOMRSGBNZ-UHFFFAOYSA-N
- SMILES
- N#Cc1ccncc1
- LogP
- 0.46 at 25℃
- CAS ??????
- 100-48-1(CAS DataBase Reference)
??
- ?? ? ?? ??
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 20/21/22 | ||
| ????? | 36/37-24/25 | ||
| ????(UN No.) | 3276 | ||
| WGK ?? | 3 | ||
| TSCA | TSCA listed | ||
| ???? | III | ||
| HS ?? | 29333999 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
||
| ???? ?? | KE-29933 |
4-?????? C??? ??, ??, ??
??? ??
beige solid??
4-Cyanopyridine is used as an intermediate in organic synthesis and pharmaceutical substances like isonicotinylhydrazide, which is used in the treatment of tuberculosis. It is used as a precursor for the preparation of isonicotinic acid and 4-diemthylaminopyridine (DMAP). It is involved in the synthesis of 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine by reacting with acetonitrile.?? ??
4-Cyanopyridine is mainly used as an important fine chemical intermediate. In the field of medicine, it is widely employed in the synthesis of antidepressants, antiviral drugs, anti-tuberculosis drugs (such as the intermediate of isoniazid), and the new drug for treating gout, Topiroxostat. Moreover, it is also a key structural unit for the synthesis of pesticides, dyes, high molecular materials, functional polymers and catalyst ligands.Synthesis
4-Cyanopyridine is synthesised by the reaction of 4-methylpyridine with ammonia and air in the presence of a catalyst. The specific synthesis steps are as follows:4-Methylpyridine and ammonia vaporisation preheating to 180-330°C, then into the mixing tank and air mixing uniformly, into the fixed-bed reactor by the top of the fixed-bed reactor after the distribution of the catalyst-filled reactor, the control of the reaction temperature in the range of 330-450 ° C, the reaction head pressure is controlled in the range of 0.020-0.070 KPa, the reaction temperature is controlled by molten salts, the reaction gas after the end of the reaction After the reaction, the reaction gas was condensed to sub-zero fractionation to obtain the crude product of 4-cyanopyridine, and the crude product was distilled to obtain the finished product of 4-cyanopyridine. The conversion rate of 4-methylpyridine was above 99%, and the yield of 4-cyanopyridine was above 98%.
??? ??
Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.?? ??
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).? ???
Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .4-?????? ?? ?? ? ???
???
?? ??
4-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID
2-TERT-BUTYLPYRIDINE-4-CARBONITRILE
2-tert-Butylpyridine-4-carboxylic acid ,97%
4-???????
3-Chloro-4-cyanopyridine
4-[(TERT-BUTOXYCARBONYLAMINO)METHYL]-2-CYANOPYRIDINE
?????
4-(BOC-AMINOMETHYL)PYRIDINE-2-CARBOXYLIC ACID
2,4-?????????
4-AMIDINOPYRIDINIUM CHLORIDE
4-(BOC-AMINOMETHYL)PYRIDINE
4-CYANOPYRIDIN-3-????
4-(4-CHLOROBENZOYL)PYRIDINE
?????(4-3?)
?????
4-PYRIDINECARBOXAMIDINE
4-??? ???
Ethyl isonicotinate
2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE
4-?????? ?? ??
???( 603)?? ??
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4-?????? ?? ??:
2-?????? ??? ?????????????(??? ??????????) ???? ??? ???????? ?? ??????? 2,6-????????? 3,4-????????? 3-?????? ???? 1-??-1,2-?????-6-?????-4-??-2-??-3-????????? 2,4-????????? 4-?????? 5-???-2-????????
2-Chloro-3-cyanopyridine
Ethyl N-cyanoethanimideate
2-Pyridinecarboxaldehyde
3-Pyridinecarboxaldehyde
3,4-Pyridinedicarboxylic acid