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Dimethicone

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? (1) ?? : ? ??? ??? 0.96～1.02??? ??.

??(2) ??? : ? ?? 20g? ??? ?? ?? 100mL? ?? ? 3?? ?? ?? 200? ?? ???? ? 10,000rpm?? 30?? ??????. ???? ?? ?? ????? ?? ?? 50mL? ??? ? ???? ? ??????. ???? ?? ? ????? 50～60℃ ????? ???? ??? ???? ?? 105℃?? 1?? ??? ?? ?????? ?? ???? ????. ?????? ???? 1.400～1.410??? ??.

??(3) ?? : (2)? ??? ???? ?? ????? 25℃?? ????? ? 1? ??? ?????? ?? ??? ?, 100～1,100 ?????????? ??.

??(4) ????? : ? (2)?? ??? ??? ???? ? 100℃?? 1?? ??? ?, ? ?? 2.25g ????? ??(15% ??).

??(5) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.

??(6) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 5.0ppm ????? ??.

??(7) ?? : ? ??? ?????? ?? ??? ?, ? ?? 1.0ppm ????? ??.

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? ? ?? 100mg? ?????? ?? ?? ? ?? ???? ?? ?? ???? ? ??? ????? ??. ? ? ??? ??? ???? ?? ?? ???? ??? ??? ????. ?? ??? ?????? ?? ?????? 3g? ??? ??? ?? ?? ? 50mL? ??? ??? ??? ??, ? ?? 1?? ? ?????????? 1??? ????? ???? ?? ????? 1??? ??? ?? ????? ??? ????? ??? ????.

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Dimethicones are clear, colorless liquids available in various viscosities. Dimethicone is a fluid mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Methicone is a linear monomethyl polysiloxane. Dimethicone are safe as used in cosmetic formulations, vulcanization.

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dimethicone is a form of silicone used to give products lubricity, slip, and good feel. It can also serve as a formulation defoamer and help reduce the feeling of greasiness that some creams leave on the skin immediately upon application. In addition, dimethicone is reported to protect the skin against moisture loss when used in larger quantities. It improves product flow and spreadability. In combination with other ingredients, dimethicone becomes a good waterproofing material for sunscreen emulsions, and helps reduce the greasiness often seen in high-SPF preparations.

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ChEBI: A polydimethylsiloxane macromolecule, composed of dimethylsiloxane repeating units.

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Dimethicone isapoly (dimethylsiloxane) obtained by hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. The hydrolysis products contain active silanol groups through which condensation polymerization proceeds. By varying the proportions of chlorotrimethylsilane, which acts as a chain terminator, silicones of varying molecular weight may be prepared. Different grades of dimethicone are produced that may be distinguished by a number placed after the name indicating the nominal viscosity. For example, ABIL 20 (Evonik Goldschmidt UK Ltd) has a nominal kinematic viscosity of 18–22mm2/s (18–22cSt).

Indications

Silicone (dimethicone) ointments are excellent water-protective agents because they have an extremely low surface tension and penetrate crevices in the skin to form a plastic-like barrier. Further, they are nontoxic, inert, stable, and water repellent. As such, they are useful as barrier creams in industry or wherever constant or frequent exposure to aqueous compounds is a problem. They will not, however, protect well against solvents, oils, or dusts.

Pharmaceutical Applications

Dimethicones of various viscosities are widely used in cosmetic and pharmaceutical formulations. In topical oil-in-water emulsions dimethicone is added to the oil phase as an antifoaming agent. Dimethicone is hydrophobic and is also widely used in topical barrier preparations. Therapeutically, dimethicone may be used with simethicone in oral pharmaceutical formulations used in the treatment of flatulence. Dimethicone is also used to form a waterrepellent film on glass containers.

Safety

Dimethicone is generally regarded as a relatively nontoxic and nonirritant material although it can cause temporary irritation to the eyes. In pharmaceutical formulations it may be used in oral and topical preparations. Dimethicones are also used extensively in cosmetic formulations and in certain food applications.
The WHO has set a tentative estimated acceptable daily intake of dimethicone with a relative molecular mass in the range of 200–300 at up to 1.5mg/kg body-weight.
Injection of silicones into tissues may cause granulomatous reactions. Accidental intravascular injection has been associated with fatalities.

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Dimethicones should be stored in an airtight container in a cool, dry, place; they are stable to heat and are resistant to most chemical substances although they are affected by strong acids. Thin films of dimethicone may be sterilized by dry heat for at least 2 hours at 160°C. Sterilization of large quantities of dimethicone by steam autoclaving is notrecommended since excesswater diffuses intothe fluid causing it to become hazy. However, thin films may be sterilized by this method. Gamma irradiation may also be used to sterilize dimethicone. Gamma irradiation can, however, cause crosslinking with a consequent increase in the viscosity of fluids.

Regulatory Status

Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets, topical creams,emulsions,lotions,and transdermal preparations).Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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???	??	???	??	?? ?	??
ENERGYCO LTD.	+86-25-83179363 +86-13951023282	99123189@qq.com	China	5	58
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd	510-85010237	overseamarketing@alphahi-tech.com	CHINA	41	58
ChemFine International Co.,Ltd.	+86-510-82753588 +86-13806194144	info@chemfineinternational.com	China	272	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8738	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3971	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5218	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-17732866630	mina@chuanghaibio.com	China	18126	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
Shaanxi TNJONE Pharmaceutical Co., Ltd		sarah@tnjone.com	China	1143	58

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