ChemicalBook >?? ???? >?? ???>??? ?? ?? ???>?? ???>1H-??-5-??????

1H-??-5-??????

1H-??-5-?????? ??? ???

?? ??:: 1670-87-7

???:: 1H-??-5-??????

???(??):: 1H-??-5-??????

???:: 1H-INDOLE-5-CARBOXAMIDE, 97%

???(??):: SD-169;SD169 ，S0388;5-CarbaMoylindole;SD-169, 10 mM in DMSO;1H-indole-5-carboxamide;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI)

CBNumber:: CB0972248

???:: C9H8N2O

??? ??:: 160.17

MOL ??:: 1670-87-7.mol

MSDS ??:: SDS

?? ?? 129

1H-??-5-?????? ??

???: 159-163 °C

?? ?: 457.6±18.0 °C(Predicted)

??: 1.328±0.06 g/cm3(Predicted)

?? ??: Sealed in dry,2-8°C

???: DMSO(?? ???), ???(?? ???)

?? ?? (pKa): 16.25±0.30(Predicted)

??? ??: ??? ??

??: ???? ?? ?????

???: water: 1mg/mL
DMSO: 10mg/mL

InChI: 1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)

InChIKey: GQMYQEAXTITUAE-UHFFFAOYSA-N

SMILES: [nH]1c2c(cc1)cc(cc2)C(=O)N

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xn
?? ???? ??	22-36/37/38
?????	26
WGK ??	WGK 3
???? ???	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	0
2		0

1H-??-5-?????? C??? ??, ??, ??

???? ??

Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

1H-??-5-?????? ?? ?? ? ???

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1H-??-5-?????? ?? ??

???( 129)?? ??

???	??	???	??	?? ?	??
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1H-??-5-?????? ?? ??:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole SD-208 FROVATRIPTAN GO 6976 K-252A 4'-demethylamino-4'-hydroxystaurosporine STAUROSPORINE ANTIBIOTIC UCN-02 1-BENZYL-2,3-DIMETHYL-1H-INDOLE-5-CARBOHYDRAZIDE 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE K-252C N-ethoxycarbonyl-7-oxostaurosporine 5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]- 5-CARBOXAMIDO[3H]TRYPTAMINE, TRIFLUOROACETATE 5-carboxamidotryptamine maleate salt 2,3-DIMETHYL-1 H-INDOLE-5-CARBOXYLIC ACID HYDRAZIDE TAN 999 N,N-DIPROPYL-5-CARBOXAMIDOTRYPTAMINE MALEATE

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