6-???????
|
|
6-??????? ??
- ???
- 125-128 °C
- ?? ?
- 343.2±15.0 °C(Predicted)
- ??
- 1.327±0.06 g/cm3(Predicted)
- ?? ??
- Sealed in dry,2-8°C
- ???
- ?????(?? ???, ??), ???(?? ???)
- ??? ??
- ???? ??? ??
- ?? ?? (pKa)
- 10.07±0.40(Predicted)
- ??
- ???? ?????
- ??? ?? ??
- ?? ??
- ??? ?? ??
- 6-Hydroxyindole (2380-86-1)
- InChI
- InChI=1S/C8H7NO/c10-7-2-1-6-3-4-9-8(6)5-7/h1-5,9-10H
- InChIKey
- XAWPKHNOFIWWNZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(O)=C2)C=C1
- CAS ??????
- 2380-86-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi,N,Xn | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-51/53-43-41-22 | ||
| ????? | 37/39-26-61-24-2 | ||
| ????(UN No.) | UN 3077 | ||
| WGK ?? | 3 | ||
| ?? ?? ?? | Irritant | ||
| ?? ?? | IRRITANT, KEEP COLD | ||
| ?? ?? | 9 | ||
| ???? | Ⅲ | ||
| HS ?? | 29339900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 Eye Dam. 1 Skin Sens. 1 |
6-??????? C??? ??, ??, ??
??? ??
White to off-white shiny crystalline powder??
- Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Reactant for asymmetrical synthesis of notoamide J as a potential biosynthetic precursor of prenylated indole alkaloids
- Reactant for preparation of (quinolinyloxymethyl)isoxazolecarboxylate esters antituberculosis agents
- Reactant for preparation of indolyl(propanolamine) derivatives as HIV inhibitors
- Reactant for preparation of indoleoxyacetic acid derivatives as peroxisome proliferator-activated receptor agonists
- Reactant for preparation of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 2419, 1992 DOI: 10.1021/jm00091a010Synthesis
Regioselective chloroacetylation of 1-pivaloylindole followed by Baeyer-Villiger oxidation offers introduction of an oxygen function into the 6-position of the indole ring. Deacylation of 6-chloroacetyl-1-pivaloylindole gives 6-hydroxyindole. The overall yield of 6-hydroxyindole from indole is 54%.
[1] K. TERANISHI; T. G; S I NAKATSUKA. ChemInform Abstract: Facile Synthesis of 6-Hydroxyindole (VII) and 6-Methoxyindole (IX) via Regioselective Friedel-Crafts Acylation and Baeyer-Villiger Oxidation.[J]. ChemInform, 1995, 26 9. DOI:10.1002/chin.199509120.
6-??????? ?? ?? ? ???
???
Aluminium-nickel
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N,N-?????????
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NICKEL BORIDE
?? ??
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N,N-????????? ??? ???
3-????-p-???
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6-??????? ?? ??
???( 462)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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