???? ???????
|
|
???? ??????? ??
- ???
- 205-206 °C (dec.)(lit.)
- ?? ??
- 2-8°C
- ???
- ?: ???50mg/mL, ??, ???~???
- ??? ??
- Solid
- ??
- Red brown to orange
- ???
- ??? ???
- Merck
- 13,7833
- BRN
- 3812133
- BCS Class
- 1 (CLogP), 3 (LogP)
- ???
- ????. ?? ???? ???? ????.
- InChI
- InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)
- InChIKey
- GJOHLWZHWQUKAU-UHFFFAOYSA-N
- SMILES
- C1(NC(C)CCCN)=CC(=CC2=CC=CN=C12)OC.P(=O)(O)(O)O.P(=O)(O)(O)O
- CAS ??????
- 63-45-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 25 | ||
| ????? | 45 | ||
| ????(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | VA9660000 | ||
| F ?????? | 10 | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| HS ?? | 29334900 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 3 Oral Muta. 2 Repr. 2 |
???? ??????? C??? ??, ??, ??
??? ??
orange powder??
Primaquine diphosphate is an established antimalarial drug used in the treatment of persistent liver forms of P. vivax or P. ovale infection for its ability to kill late-stage gametocytes and hypnozoites. In historical terms, this aminoquinoline was the stimulus for the discovery of glucose-6-phosphate (G6P) dehydrogenase deficiency as it induced hemolytic anemia in patients lacking the G6P-metabolizing enzyme.Purification Methods
It forms yellow crystals from 90% aqueous EtOH and is moderately soluble in H2O. The oxalate salt has m 182.5-185o (from 80% aqueous EtOH), and the free base is a viscous liquid b 165-170o/0.002mm, 175-177o/2mm. [Elderfield et al. J Am Chem Soc 68 1526 1964, Elderfield et al. J Am Chem Soc 77 4817 1955, Beilstein 22 III/IV 5817.]???? ??????? ?? ?? ? ???
???
1H-Isoindole-1,3(2H)-dione, 2-[4-[(6-methoxy-8-quinolinyl)amino]pentyl]-
????
8-???-6-??????
6-METHOXY-8-NITROQUINOLINE
4-???-2-???????
?? ??
???? ??????? ?? ??
???( 301)?? ??
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