??? ??????
|
|
??? ?????? ??
- ???
- 176-180 °C(lit.)
- ??
- 1.457[at 20℃]
- ???
- 0.003Pa at 20℃
- ?? ??
- 2-8°C
- ??? ??
- ??? ??
- ??
- ???? ?? ??
- ???? ??
- synthetic
- ???
- ?? ???
- ??
- Hygroscopic
- Merck
- 14,4491
- BRN
- 3909617
- ?? ??
- food and beverages
- ??? ?? ??
- BUFFERING
- InChI
- InChI=1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
- InChIKey
- IVLXQGJVBGMLRR-UHFFFAOYSA-N
- SMILES
- C(=O)(O)CN.Cl
- LogP
- -3.25 at 20℃
- CAS ??????
- 6000-43-7(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ???? ?? | 22 | ||
|---|---|---|---|
| ????? | 24/25-44 | ||
| ????(UN No.) | UN 1789 8/PG 3 | ||
| WGK ?? | 2 | ||
| RTECS ?? | MC0560000 | ||
| F ?????? | 10 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29224999 | ||
| ???? ??? | 8B - Non-combustible corrosive hazardous materials | ||
| Hazard Classifications | Eye Irrit. 2 Met. Corr. 1 Skin Irrit. 2 |
||
| ???? ?? | KE-18057 |
??? ?????? C??? ??, ??, ??
??? ??
white crystals or crystalline powder??
Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Glycine Hydrochloride is commonly used in buffer solutions, in electrophoresis, and preparative chromatography.?? ??
Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle.synthesis of Glycine hydrochloride
??
Glycine hydrochloride is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.Purification Methods
Crystallise the salt from absolute EtOH or 80% EtOH. Monoglycine hydrochloride has m 176-177o, and diglycine monohydrochloride has m 187o. [Frost J Am Chem Soc 64 1286 1942, Beilstein 4 III 1111, 4 IV 2353.]??? ?????? ?? ?? ? ???
???
2-(2,2,2-??????????)????
isonitroso-
(2,2,2-??????-??????)-??????????
N-(Methoxycarbonyl)glycine Methyl Ester
L-Proline hydrochloride
???(???????)????? ?????
??
L-Isoleucine hydrochloride
???
???
????
???????? ? ??? ????
?? ??
??? ?????? ?? ??
???( 320)?? ??
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??? ?????? ?? ??:
??? ??? ????? ???? D-4-????????? ??? ???????? ????????? ?????? ????????? ????? ???? ?? ???? ??? ?????? ???????
4-Aminophenylacetic acid
Glycine methyl ester hydrochloride
Topotecan hydrochloride
Ethyl L-phenylalaninate hydrochloride
DL-4-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE
Methyl L-leucinate hydrochloride
1-Aminocyclopropane-1-carboxylic acid hydrochloride
DL-4-Chlorophenylalanine methyl ester hydrochloride
Betaine hydrochloride
CHLOROACETYL-L-TYROSINE