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Triclabendazole

Triclabendazole ??? ???

?? ??:: 68786-66-3

???:: Triclabendazole

???(??):: Tricalbendazole;Triclabendazol;6-CHLORO-5-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-BENZIMIDAZOLE;5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-1H-BENZIMIDAZOLE;FASINEX;CGA-89317;snalvbendaz;TRICLABENDAZOLE;CGA-89317, Egaten;Triclabendazole EP

CBNumber:: CB1282896

???:: C14H9Cl3N2OS

??? ??:: 359.66

MOL ??:: 68786-66-3.mol

MSDS ??:: SDS

MSDS

?? ?? 441

Triclabendazole ??

???: 175-176°C

?? ?: 240.6°C (rough estimate)

??: 1.3875 (rough estimate)

???: 1.6000 (estimate)

?? ??: Sealed in dry,Room Temperature

???: ??????(?? ???,??? ??), ??? (?? ???)

??? ??: Solid

?? ?? (pKa): 7.91±0.10(Predicted)

??: ???? ????

Merck: 14,9652

BCS Class: 4/3

???: ??

?? ??: ?? ??

InChI: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

InChIKey: NQPDXQQQCQDHHW-UHFFFAOYSA-N

SMILES: C1(SC)NC2=CC(Cl)=C(OC3=CC=CC(Cl)=C3Cl)C=C2N=1

CAS ??????: 68786-66-3(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xi
?? ???? ??	36/37/38
?????	26-36-24/25
WGK ??	3
RTECS ??	DD6747000
HS ??	29339900
???? ???	11 - Combustible Solids
??	LD50 oral in rabbit: 206mg/kg

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	1
2		0

Triclabendazole MSDS

6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole

Triclabendazole C??? ??, ??, ??

??

Triclabendazole is a benzimidazole anthelmintic. It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg. Triclabendazole (5 μM) also protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway.

??? ??

Off-White Solid

??

Triclabendazole is classified under the category of ‘Anthelmintic flukicide for veterinary use.

Synthesis

Synthesis of Triclabendazole
Triclabendazole synthesis

Triclabendazole ?? ?? ? ???

???

5-chloro-6-(2,3-dichorophenoxy)-2-thio-1H-benzimidazole ??? ?? ??????? ? ????? ?????

?? ??

Triclabendazole ?? ??

???( 441)?? ??

???	??	???	??	?? ?	??
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Triclabendazole ?? ??:

????? ??? ???? ????? 1,2,4-???????? Triethanolamine Nitroxinil Oxyclozanide Tilmicosin phosphate Triclabendazole Triclabendazole sulfoxide 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE 5-Chloro-2-mercaptobenzimidazole 5-METHOXYBENZIMIDAZOLE 2-(METHYLTHIO)BENZIMIDAZOLE 5-METHOXY-2-(METHYLTHIO)BENZIMIDAZOLE 1H-Benzimidazol-5-ol 5-HYDROXY-2-MERCAPTO-BENZIMIDAZOLE 6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE

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