????????
|
|
???????? ??
- ???
- 203-204 °C (lit.)
- ?? ?
- 437.26°C (rough estimate)
- ??
- 60 º (c=2, EtOH)
- ??
- 0.9985 (rough estimate)
- ???
- 60.5 ° (C=2, EtOH)
- ???
- 9℃
- ?? ??
- 2-8°C
- ???
- ???: 50mg/mL, ??
- ?? ?? (pKa)
- pKa 5.04±0.04(H2O t = 25.0±0.1 I = 0.00)(Approximate)
- ??? ??
- ???. ??.
- ??
- ?? - ?? ?????.
- ???
- ????? ???
- Merck
- 14,9889
- BRN
- 3219888
- ??? ?? ??
- ?? ???? - ??
?? ??
- InChIKey
- RUDATBOHQWOJDD-UZVSRGJWSA-N
- SMILES
- C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
- LogP
- 3-3.38 at 20℃
- CAS ??????
- 128-13-2(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 24/25-36-26 | ||
| ????(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
| WGK ?? | 2 | ||
| RTECS ?? | FZ2000000 | ||
| F ?????? | 10 | ||
| HS ?? | 29181990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
||
| ?? | LD50 in mice (g/kg): 0.1 i.v. (Ardenne, Reitnauer); in rats, mice (mg/kg): 2000, 6000 s.c.; 1000, 1200 i.p., 310, 260 i.v. (Ward) |
???????? C??? ??, ??, ??
??? ??
WHITE CRYSTALLINE POWDER??
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response. It is also used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.??
ChEBI: Ursodeoxycholic acid is a bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of an ursodeoxycholate.?? ??
Ursodeoxycholic acid (UDCA) is a secondary bile acid that helps regulate cholesterol. Mass spectrometry-based analysis of UDCA is routinely performed in clinical diagnostic testing applications such as neonatal testing of inborn errors of bile acid synthesis, differentiating among types of familial intrahepatic cholestasis, and therapeutic monitoring of patient responses to UDCA therapy. This Certified Spiking Solution is suitable as a starting material in preparation of linearity standards, calibrators, and controls for use in LC-MS/MS and GC/MS bile acid testing methods.Purification Methods
Recrystallise ursodiol from wet Et2O, EtOH or EtOH/MeOH. [Iwasaki Hoppe Seyler's Z Physiol Chem 244 181, 183 1936, Beilstein 10 III 1635.]???????? ?? ?? ? ???
???
????? ???
2,3-????
????
CHOLIC ACID METHYL ESTER
??? ??
????
Acetylcholic acid
5β-???
????(???)
??
??(6+) ?????
???
?? ??
???????? ?? ??
???( 930)?? ??
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???????? ?? ??:
?? ???? ????? ?? ? ???? ??? ??? ???????? TAUROURSODEOXYCHOLICACID????
Hyaluronic acid
Solvent Red 43
Deoxycholic acid
URSODEOXYCHOLIC-2,2,4,4-D4 ACID
Bromothymol Blue
URSODEOXYCHOLIC ACID-24-13C
Ascoric Acid
3-epi-Ursodeoxycholic acid
(+)-NEOMENTHOL
(2R,5S)-5-(5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester