Cyclopenthiazide
Cyclopenthiazide ??
???
230°
?? ?
605.6±65.0 °C(Predicted)
??
1.3650 (rough estimate)
???
1.6100 (estimate)
?? ??
Refrigerator
???
?????? (?? ???), DMSO (?? ???), ???(???)
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??? ??
?? ?? (pKa)
9.00±0.40(Predicted)
??
???? ?????
???
50mg/L(??)
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InChI
1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)
InChIKey
BKYKPTRYDKTTJY-UHFFFAOYSA-N
SMILES
[S]1(=O)(=O)NC(Nc3c1cc(c(c3)Cl)[S](=O)(=O)N)CC2CCCC2
CAS ??????
742-20-1(CAS DataBase Reference)
EPA
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1)
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?? ? ???? ?? (GHS)
WGK ??
WGK 1
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11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
??
LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)
????(GHS):
?? ?:
Warning
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P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
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?? 2
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P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
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?? 2A
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P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ??
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?? 3
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H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ??
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?? 2
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P260, P314, P501
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P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
Cyclopenthiazide C??? ??, ??, ??
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Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
World Health Organization (WHO)
Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It
continues to be used mainly in combination drugs.
Cyclopenthiazide ?? ?? ? ???
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Cyclopenthiazide ?? ??
???( 119)?? ??
Canada 1
China 105
Germany 1
India 1
Thailand 1
United Kingdom 4
United States 6
Global 119
