??
|
|
?? ??
- ???
- 229-231 °C(lit.)
- ?? ?
- 310.05°C (rough estimate)
- ??
- 1.2196 (rough estimate)
- ???
- 1.5557 (estimate)
- ?? ??
- -20°C
- ???
- DMSO: ??? ? ??
- ??? ??
- ??
- ??
- ???
- Merck
- 14,9735
- BRN
- 221723
- InChI
- 1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
- InChIKey
- FMHHVULEAZTJMA-UHFFFAOYSA-N
- SMILES
- Cc1cc2cc3C(C)=CC(=O)Oc3c(C)c2o1
- CAS ??????
- 3902-71-4
- IARC
- 3 (Vol. 40, Sup 7) 1987
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | C | ||
|---|---|---|---|
| ?? ???? ?? | 34-40 | ||
| ????? | 26-36/37/39-45 | ||
| ????(UN No.) | UN 1759 8/PG 1 | ||
| WGK ?? | 2 | ||
| RTECS ?? | LV1576000 | ||
| F ?????? | 8-10 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 8 | ||
| ???? | III | ||
| HS ?? | 29322985 | ||
| ???? ??? | 8A - Combustible corrosive hazardous materials | ||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Eye Dam. 1 Muta. 2 Skin Corr. 1B |
||
| ???? ?? | KE-34519 |
?? C??? ??, ??, ??
??? ??
White to slightly beige crystalline powder??
Trioxsalen has been used:- to induce small deletion mutations in worms
- in combination with ultraviolet A (UVA)
- to induce interstrand crosslinks (ICLs) in DNA
- for the preparation and photoactivation of trimethyl psoralen
Indications
Trioxsalen (Trisoralen) followed by UVA exposure is used to repigment vitiliginous areas and in photochemotherapy.??
ChEBI: 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phot therapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermi .Purification Methods
Purify trioxsalen by recrystallisation from CHCl3. If too impure, it is fractionally crystallised from CHCl3/pet ether (b 30-60o) using Norit and finally crystallised from CHCl3 alone to give colourless prisms, m 234.5-235o. It is a photosensitiser so it should be stored in the dark. [UV: Kaufmann J Org Chem 26 117 1961, Baeme et al. J Chem Soc 2976 1949, Beilstein 19/4 V 472.]?? ?? ?? ? ???
???
???????
?????
???
?? ??
1,3- ??, 2- ??
????
????
??????
N,N-??????
??????
1,2,3-????????
?? ??
??
???
2H-1-Benzopyran-2-one, 7-[(2-chloro-2-propenyl)oxy]-4,8-dimethyl-
7-ALLYLOXY-4,8-DIMETHYL-CHROMEN-2-ONE
6-allyl-7-hydroxy-4,8-dimethyl-2H-chromen-2-one
7-?????-4,8-??????
?? ??
?? ?? ??
???( 148)?? ??
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?? ?? ??:
??
Psoralen
3-(HYDROXYMETHYL)-2,5,9-TRIMETHYL-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE
PSORALEN-C 6 CEP
Trioxsalen, 4-Aminomethyl-, HCl
3-(2-HYDROXY-ETHOXYMETHYL)-2,5,9-TRIMETHYL-FURO[3,2-G]CHROMEN-7-ONE
3-CHLOROMETHYL-2,5,9-TRIMETHYL-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE
PSORALEN-C 2 CEP
3-(6-HYDROXYHEXYL)METHYL-2,5,9-TRIMETHYL-7H-FURO[3,2-G]-[1]BENZOPYRAN-7-ONE
TRIOXSALEN(RG)
1-(O-B-D-GALACTOPYRANOSYL)*METHYL TRIOXSALEN
1-(O-BETA-D)-GALACTOPYRANOSYL)METHYL TRIOXSALEN
1-(O-?-D)-GALACTOPYRANOSYL)METHYL TRIOXSALEN
1,15-bis(4'-trioxsalen)-2,6,10,14-tetramethyl-2,6,10,14-tetrazapentadecane
TRIOXSALEN, 4'-AMINOMETHYL-, HYDROCHLORIDE
TRIOXSALEN, 4'-HYDROXYMETHYL-
3-(2-AMINOOXY-ETHOXYMETHYL)-2,5,9-TRIMETHYL-FURO[3,2-G]CHROMEN-7-ONE
3-(2-AMINO-ETHOXYMETHYL)-2,5,9-TRIMETHYL-FURO[3,2-G]CHROMEN-7-ONE