Dihydrocaffeic acid
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Dihydrocaffeic acid ??
- ???
- 136-139 °C(lit.)
- ?? ?
- 418℃
- ??
- 1.398
- ???
- 220℃
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- DMSO(?? ???), ???(?? ???)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 4.75±0.10(Predicted)
- ??
- ??????? ???????
- ???
- ?? ?? ?????.
- BRN
- 2213449
- InChI
- InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)
- InChIKey
- DZAUWHJDUNRCTF-UHFFFAOYSA-N
- SMILES
- C1(CCC(O)=O)=CC=C(O)C(O)=C1
- LogP
- 0.115 (est)
- CAS ??????
- 1078-61-1(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | MW5143500 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Dihydrocaffeic acid C??? ??, ??, ??
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Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties. Dihydrocaffeic acid scavenges ABTS (; IC50 = 81.86 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; ; IC50 = 192.86 μg/ml) radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine (SNAP; ) in a concentration-dependent manner. It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner. In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).??? ??
Brown Solid??
Dihydrocaffeic Acid is a natural product containing a catechol group with an α,β-unsaturated carboxylic acid chain. Dihydrocaffeic Acid has been shown to have hepatoprotective activity. Dihydrocaffei c Acid is a metabolite of Caffeic Acid (C08000) with potent antioxidant properties.??
ChEBI: A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. It is a metabolite of caffeic acid and exhibits antioxidant activity.Dihydrocaffeic acid ?? ?? ? ???
???
Palladium hydroxide
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tert-?????
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3,4-???????????
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Dihydrocaffeic acid ?? ??
???( 295)?? ??
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Dihydrocaffeic acid ?? ??:
???? 3-(3,4,5-???????)????? 3,4-???????-??-??????? ????? ????
DL-DOPA
(2S)-2-Amino-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid
3-(3,4-METHYLENEDIOXYPHENYL)PROPIONIC ACID
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
Dihydrocaffeic acid
CINOXACIN
3,4-Dimethoxyhydrocinnamic acid
Levodopa
(2RS,3RS)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-3-HYDROXY-PROPIONIC ACID
BETANIN
ETHYL 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONATE
DROXIDOPA
DL-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid