Ryanodine
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Ryanodine ??
- ??
- D25 +26° (methanol)
- ?? ?
- 586.95°C (rough estimate)
- ??
- 1.2805 (rough estimate)
- ???
- 1.6000 (estimate)
- ?? ??
- Sealed in dry,2-8°C
- ???
- DMSO: ???10mg/mL, ??
- ??? ??
- ?? ??
- ???
- 219-220 °C
- ?? ?? (pKa)
- 10.66±0.70(Predicted)
- ??
- ???? ????
- ???
- water: 1mg/mL
methanol: 20mg/mL
- InChIKey
- JJSYXNQGLHBRRK-YSOSZROBSA-N
- SMILES
- [nH]1c(ccc1)C(=O)O[C@H]2[C@@]3([C@]4([C@]65O[C@]([C@]4([C@@]2(O)C(C)C)C)(C[C@]3([C@]6(CC[C@@H]([C@H]5O)C)O)C)O)O)O
- CAS ??????
- 15662-33-6
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,N | ||
|---|---|---|---|
| ?? ???? ?? | 21/22-50/53 | ||
| ????? | 36/37-60-61 | ||
| ????(UN No.) | UN 3077 9/PG 3 | ||
| WGK ?? | WGK 3 | ||
| RTECS ?? | VM4025000 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 |
| ????(GHS): |
 
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| ?? ?: | Warning | ||||||||||||||
| ??·?? ??: |
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Ryanodine C??? ??, ??, ??
??
Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).??? ??
white to off-white solid??
Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.??
ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.???? ??
Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).?? ??
Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)
Ryanodine ?? ?? ? ???
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?? ??
Ryanodine ?? ??
???( 134)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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Ryanodine ?? ??:
1,4-????????? ?????? ???????-1,2-??
CYCLODODECYL FORMATE
CYCLODODECANE
CYCLOOCTANEMETHANOL
2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
Ryanodine
trans-1,2-Cyclopentanediol
CYCLODODECYLMETHYL ETHER
CIS-1,2-CYCLOOCTANEDIOL
(1S)-TRANS-1,2-CYCLOPENTANEDIOL
(1R)-TRANS-1,2-CYCLOPENTANEDIOL MONOACETATE
(3S,5S)-2,6-Dimethyl-3,5-heptanediol
(R,R)-(-)-1,2-CYCLODODECANEDIOL
CIS-P-MENTHANE-3,8-DIOL
3-Deoxyryanodol
(S,S)-(+)-1,2-CYCLODODECANEDIOL