?????
|
|
????? ??
- ???
- 2 °C (lit.)
- ?? ?
- 231 °C (lit.)
- ??
- 1.238 g/mL at 25 °C (lit.)
- ?? ??
- 4.66 (vs air)
- ???
- 34 mm Hg ( 131 °C)
- ???
- n
20/D 1.642(lit.)
- FEMA
- 3256 | BENZOTHIAZOLE
- ???
- >230 °F
- ?? ??
- Keep in dark place,Inert atmosphere,Room temperature
- ???
- 3g/L
- ??? ??
- ??
- ?? ?? (pKa)
- 0.85±0.10(Predicted)
- ??
- ??? ???~??
- ??
- ??? ??, ??? ?-? ??
- ????
- 0.9-8.2%(V)
- ?? ??
- ???
- ???? ??
- synthetic
- ???
- ?? ???
- Merck
- 14,1107
- JECFA Number
- 1040
- BRN
- 109468
- Henry's Law Constant
- 2.7×101 mol/(m3Pa) at 25℃, HSDB (2015)
- ???
- ??? - ??? ?? ???? ?? ?? ??? ?????. ?? ???? ???? ????. ?? ???: ?? ???, ?????, ?????, ????.
- ??? ?? ??
- ??
- InChI
- 1S/C7H5NS/c1-2-4-7-6(3-1)8-5-9-7/h1-5H
- InChIKey
- IOJUPLGTWVMSFF-UHFFFAOYSA-N
- SMILES
- c1ccc2scnc2c1
- LogP
- 2.01
- CAS ??????
- 95-16-9(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,T,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 22-20/21/22-36-25-24-20 | ||
| ????? | 23-26-36-36/37-45 | ||
| ????(UN No.) | 2810 | ||
| WGK ?? | 2 | ||
| RTECS ?? | DL0875000 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 6.1 | ||
| ???? | III | ||
| HS ?? | 29342080 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Oral Acute Tox. 4 Inhalation Eye Irrit. 2 |
||
| ?? ?? ??? | 95-16-9(Hazardous Substances Data) | ||
| ?? | LD50 i.v. in mice: 95±3 mg/kg (Domino) | ||
| ???? ?? | KE-02722 |
????? C??? ??, ??, ??
??
Benzothiazole and its derivative are recognized as the most important heterocyclic compounds. This series of compounds is of particular interests. It has various kinds of pharmacological properties and has been included in many kinds of natural products and pharmaceutical agents. The broad spectrum of pharmacological activity in individual benzothiazole derivative enables it to serve as unique and valuable scaffolds for experimental drug design. It is already known that benzothiazole and its derivative has various biological applications including anticancer, antimicrobial, anticonvulsant, antiviral, antidiabetic, antipsychotic, antiinflammatory, analgesic, fungicidal and diuretic. Its derivatives also have many applications in polymer chemistry, dyes, drugs, and silver photography as well as rubber industry.??? ??
Benzothiazole has a delicate, persistent, rose-like odor similar to that of quinoline.??
Reported found in apricot, cooked asparagus, mozzarella cheese, skim milk powder, roasted beef, beer, malt whiskey, coconut meat, fresh mango, cooked broccoli and kelp.??
Various benzothiazole-benzamides synthesized were evaluated for their analgesic and antidepressant activities.?? ??
By refluxing a mixture of zinc o-aminophenylsulfide and formic acid, followed by steam distillation of the alkalized reaction mixture; by heating formanilid or dimethylaniline with sulfur; by oxidation of 2-mercaptobenzothiazole or of the corresponding disulfide.??
ChEBI: An organic heterobicyclic compound that is a fusion product between benzene and thiazole. The parent of the class of benzothiazoles.?? ??
Benzothiazole, a volatile sulfur-containing heterocyclic compound, is one of the key odorants of heated milk. It is also reported to occur as a flavor component of miso, coconut meat and cooked-beef.???
Highly toxic by ingestion.Safety Profile
Poison by ingestion,intraperitoneal, intravenous, and possibly other routes.When heated to decomposition it emits very toxic fumesof SOx, CN, and NOx.?? ??
Gupta, Akhilesh, and S. Rawat. "Synthesis and cyclization of benzothiazole." J. of Current Pharmaceutical Research 3.1 (2010): 13-25.Keri, Rangappa S., et al. "A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry." European journal of medicinal chemistry 89 (2015): 207-251.
Khokra, Sukhbir L., et al. "Common methods to synthesize benzothiazole derivatives and their medicinal significance: a review." International Journal of Pharmaceutical Sciences and Research 2.6 (2011): 1356.
????? ?? ?? ? ???
???
?? ??
????? ?? ??
???( 513)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Jinan Qinmu Fine Chemical Co.,Ltd. | 18660799346 |
sales@qinmuchem.com | China | 1006 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 |
admin@hblongbang.com | China | 972 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 |
Sibel@chuanghaibio.com | China | 8737 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 |
sales1@chuanghaibio.com | China | 5218 | 58 |
| Anhui Ruihan Technology Co., Ltd | +undefined17756083858 |
daisy@anhuiruihan.com | China | 954 | 58 |
| airuikechemical co., ltd. | +86-18353166132 |
sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | 13343047651 |
admin@zlchemi.com | China | 3689 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +86-13153039501 |
info@deshangchem.com | China | 659 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 |
sales@xinhepharma.com | China | 808 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 |
L18532138899@163.com | China | 939 | 58 |
????? ?? ??:
2-????????? 2-????????? 2-???????? 2-????????? ?????? ????? N-??????-?????? ????? ?????
Diltiazem hydrochloride
2-Amino-6-chlorobenzothiazole
2-Amino-6-methylbenzothiazole
2-Methyinaphtho[1,2-d]thiazole
2-Amino-6-methoxybenzothiazole
DIRECT PURE YELLOW 5G
2-(4-PIPERIDINYL)-1,3-BENZOTHIAZOLE
Thiazole
2,7-DICHLORO-4-METHYL-1,3-BENZOTHIAZOLE
2,5-DICHLORO-4-METHYL-1,3-BENZOTHIAZOLE
2-(6-CHLORO-3-PYRIDINYL)-1,3-BENZOTHIAZOLE