4-Methoxyfuro[2,3-b]quinolin-8-ol
4-Methoxyfuro[2,3-b]quinolin-8-ol ??? ???
?? ??:
2255-50-7
???:
4-Methoxyfuro[2,3-b]quinolin-8-ol
???(??):
Robustine;NPLC 0314;8-Hydroxydictamnine;8-hydroxy dictanmnine;Robustine (Haplophyllum);4-Methoxyfuro[2,3-b]quinolin-8-ol;Furo[2,3-b]quinolin-8-ol, 4-methoxy-;alkaloid,phosphodiesterase,Phosphodiesterase (PDE),Robustine,PDE5A,inhibit,Inhibitor
CBNumber:
CB22149972
???:
C12H9NO3
??? ??:
215.2
MOL ??:
2255-50-7.mol
4-Methoxyfuro[2,3-b]quinolin-8-ol ??
???
148-149℃ (ethanol )
?? ?
411.9±40.0 °C(Predicted)
??
1.378±0.06 g/cm3(Predicted)
?? ??
4°C, protect from light
??? ??
Solid
?? ?? (pKa)
5.34±0.30(Predicted)
??
White to off-white
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Danger
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H314 ??? ?? ??? ?? ??? ???
????? ?? ?????
?? 1A, B, C
??
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 ????? ?? ??? ??? ? ??
?? ??? ??
?? 1
??
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H410 ??? ??? ?? ????? ?? ???
?? ????? ?? - ??
?? 1
??
P273, P391, P501
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P272 ??? ??? ??? ??? ???? ???.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P330+P331 ???? ?? ?????. ??? ?? ?? ???.
P303+P361+P353 ??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P333+P313 ????? ?? ??? ???? ???? ??·??? ????.
P391 ???? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
4-Methoxyfuro[2,3-b]quinolin-8-ol C??? ??, ??, ??
??
Haplophyllum robustum Bge. yields this alkaloid which forms colourless crystals from EtOH. It forms a series of crystalline salts and derivatives including the hydrochloride, m.p. 199-200°C; picrate, m.p. I 79-180°C; acetyl derivative, m.p.174-5°C; methyl derivative, m.p. 140-2°C and the tetrahydrG compound with
m.p.201-2°C.
??
ChEBI: A quinoline alkaloid that is furo[2,3-b]quinoline substituted by a methoxy and a hydroxy group at positions 4 and 8 respectively.
?? ??
Fakhritdinova, Sidyakin, Yunusov,Khim. Prir.Soedin., 1, 107 (1965)
Faizutdinova, Yunusov, ibid, 3, 260 (1967)
Narasimhan, Paradkar, Alurkar, Tetrahedron, 27,1351 (1971)
4-Methoxyfuro[2,3-b]quinolin-8-ol ?? ?? ? ???
???
?? ??
4-Methoxyfuro[2,3-b]quinolin-8-ol ?? ??
???( 102)?? ??
Canada 1
China 95
United States 6
Global 102
4-Methoxyfuro[2,3-b]quinolin-8-ol ?? ??:
