??(--)
|
|
??(--) ??
- ???
- 5-6 °C(lit.)
- ?? ?
- 192-194 °C(lit.)
- ??
- [α]D20 -50～-60° (c=4, C2H5OH)
- ??
- 0.948 g/mL at 25 °C(lit.)
- ???
- 2.149hPa at 20℃
- FEMA
- 4519 | L-FENCHONE
- ???
- n
20/D 1.461(lit.)
- ???
- 127 °F
- ?? ??
- 2-8°C
- ???
- ?????(?? ???), ???(?? ???, ?????)
- ??? ??
- ??
- ??
- ????~???
- ??
- 100.00%??. ?? ?? ? ?? ??
- ?? ??
- ??? ??
- ???? ??
- synthetic
- ??? (Optical Rotation)
- [α]24/D 50.5°, neat
- ???
- 1.983g/L at 20℃
- JECFA Number
- 2200
- BRN
- 2042710
- Dielectric constant
- 12.0（20℃）
- ?? ??
- flavors and fragrances
- ??? ?? ??
- PERFUMING
- InChI
- 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- InChIKey
- LHXDLQBQYFFVNW-OIBJUYFYSA-N
- SMILES
- CC1(C)C2CCC(C)(C2)C1=O
- LogP
- 2.54 at 20℃
- CAS ??????
- 7787-20-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ???? ?? | 10 | ||
|---|---|---|---|
| ????? | 23-24/25 | ||
| ????(UN No.) | UN 1224 3/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | RB7875000 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 3 | ||
| ???? | III | ||
| HS ?? | 29142900 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Aquatic Chronic 2 | ||
| ?? | The acute oral LD50 value in rats was reported as 616 g/kg (Jenner, Hagan, Taylor. Cook & Fitzhugh, 1964) and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Leven-stein, 1975). |
??(--) C??? ??, ??, ??
??? ??
CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID??
Reported to be found in many essential oils, including those of Thuja plicata, T.occiden-talis, T.standi shii, Russian anise, fennel, a few Artemisia varieties (A. frigida, A . verlotorum and A . santolinaefolia), Lavandula stoechas and L. burmannii. The highest levels (12-19%) are found in fennel oil (Fenarolis Handbook of Flavor Ingredients, 1975; Gildemeister & Hoffman, 1963).??
(1R,4S)-1,3,3-Trimethylbicyclo[2.2.1]heptan-2-one also known more commonly as (-)-Fenchone is a chiral intermediate of Fenchone and is currently being used for studies ranging from inhibitory effects of monoterpenes on human TRPA1 and odorant receptor of the malaria vector Anopheles gambiae.?? ??
By isolation from cedar leaf oil (Thuja oil) or by various synthetic methods (Arctander, 1969).??
ChEBI: A fenchone that has (1R,4S)-stereochemistry. It is a constituent of the essential oils obtained from fennel.?? ??
(1R)-(-)-Fenchone is a bridged bicyclic ketone found in fennel oil and thuja oil.Pharmacology
In mice, fenchone injected sc in sesame oil produced clonic convulsions at non-lethal doses, with a median convulsive dose (CD50) of 1133 mg/kg, and a dose of 500 mg/kg given sc was an effective arousal agent, reducing the hexobarbitone sleep time (Wenzel & Ross, 1957). In rats, an ip dose of 500 mg/kg had no effect on pentobarbitone-depressed respiration, while ip doses of 50-400 mg/kg increased running activity but did not affect total activity (Wenzel & Ross, 1957). Fenchone showed some antispasmodic action on excised mouse intestine (Haginiwa, Harada & Morishita, 1963), and at 260 mmol/kg showed good choleretic properties of moderately long duration when given orally in olive oil to rats (Mrsdorf, 1966). Thomas (1958) reported that it acted as a central nervous system stimulant. Fenchone has been used medically as a counter-irritant (Merck Index, 1968).?? ??
Rimini (1901 & 1909) showed that, in the dog, fenchone was probably oxidized to 4-hydroxyfenchone. Reinartz & Zanke (1936) showed that there were other products. They separated, as lead salts, the glucuronides from the urine of dogs receiving d-fenchone. The lead was removed with sulphuric acid and the resulting solution was hydrolysed. In the resulting mixture of hydroxyfen chones, the presence of 4- and 5-hydroxyfenchones and 7r-apofenchone-3-carboxylic acid was demon strated (Williams, 1959).Purification Methods
Purification is as for the (+)-enantiomer above and should have the same physical properties except for opposite optical rotations. UV has max 285nm ( 12.29). [Braun & Jacob Chem Ber 66 1461 1933, UV: Ohloff et al. Chem Ber 90 106 1957.] [Beilstein 7 III 392, 7 IV 212.]??(--) ?? ?? ? ???
???
???? ??
Bicyclo[2.2.1]heptane-2-selone, 1,3,3-trimethyl-, (1R,4S)-
Bicyclo[2.2.1]heptan-2-one, 1,3,3-trimethyl-, oxime, (1R,4S)-
methyl 3-(tert-butyldimethylsilyloxy)benzoate
(+)-Fenchol
Methyl 3-hydroxybenzoate
Methyl 3-methoxybenzoate
?? ??
??(--) ?? ??
???( 195)?? ??
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|---|---|---|---|---|---|
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??(--) ?? ??:
??(+-)
Anisole
trans-Anethole
Cinnamaldehyde
cis-Anethol
Cornmint oil
Fenchone
(1S)-(+)-Camphor-10-sulphonic acid
fenchone xoime,fenchone xoime
(+)-FENCHONE,FENCHONE, (+)-,D-FENCHONE,D(+)-FENCHONE,(+)-FENCHONE,FENCHONE, (+)-,D-FENCHONE,D(+)-FENCHONE
FENCHONE, (-)-(SG),FENCHONE, (-)-(SG)
Levo Alpha Fenchone 98%,Levo Alpha Fenchone 98%
α,Thujone, β-Thujone, Fenchone Mixture,α,Thujone, β-Thujone, Fenchone Mixture
(D)OR(+)-FENCHONE,(D)OR(+)-FENCHONE
D-FENCHONE, 96,L-FENCHONE 95%,D-FENCHONE, 96,L-FENCHONE 95%
(L)OR(-)-FENCHONE,(L)OR(-)-FENCHONE
FENCHONE, (-)-(SECONDARY STANDARD),FENCHONE, (-)-(SECONDARY STANDARD)
Fenchone isoxime,Fenchone isoxime