6-Bromoquinoline
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6-Bromoquinoline ??
- ???
- 19°C
- ?? ?
- 116 °C / 6mmHg
- ??
- 1.538 g/mL at 25 °C
- ???
- n20/D 1.663
- ???
- 19 °C
- ?? ??
- Inert atmosphere,2-8°C
- ???
- ???, ??????, ??????, ?? ????? ? THF? ?????.
- ?? ?? (pKa)
- 4.18±0.10(Predicted)
- ??? ??
- ??
- ??
- Light yellow to brown
- InChI
- InChI=1S/C9H6BrN/c10-8-3-4-9-7(6-8)2-1-5-11-9/h1-6H
- InChIKey
- IFIHYLCUKYCKRH-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(Br)=CC=2)C=CC=1
- CAS ??????
- 5332-25-2(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi,Xn | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-41-37/38-22-20/21/22 | ||
| ????? | 26-37/39-39-36 | ||
| WGK ?? | 3 | ||
| TSCA | TSCA listed | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 29334900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
6-Bromoquinoline C??? ??, ??, ??
??? ??
Thick Oil??
6-Bromoquinoline is used as fine chemical and pharmaceutical intermediate, used as the coupling reagent.Synthesis
4-Bromobenzenamine (25 g, 145.32 mmol, 1.00 equiv), sodium 3-nitrobenzenesulfonate (55.5 g, 246.64 mmol, 1.70 equiv), propane-1,2,3-triol (50.8 g, 551.63 mmol, 3.80 equiv), and sulfuric acid (170 mL, 70%) were placed into a 500-mL round-bottom flask. The resulting solution was stirred overnight at 140° C. The pH value of the solution was adjusted to with 10% aqueous sodium hydroxide. The resulting solution was extracted with 5*150 mL of ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:50). This resulted in 17.2 g (42%) of 6-bromoquinoline as yellow oil.6-Bromoquinoline ?? ?? ? ???
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1-Bromo-4-nitrobenzene
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???-1,4-????
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n-???
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4-??????
6-QUINOLINYL TRIFLUOROMETHANESULFONATE
6,8-dibroMo-1,2,3,4-tetrahydroquinoline
6-bromo-1-oxido-quinoline
6-???-1,2,3,4-?????????
?? ??
6-Bromoquinoline ?? ??
???( 468)?? ??
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|---|---|---|---|---|---|
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6-Bromoquinoline ?? ??:
3,7-????-8-??????? 8-???????? ???? ????? ????? 6-???-2-?????
6-Hydroxy-2(1H)-3,4-dihydroquinolinone
quinolinium hydrogen sulphate
6-Bromoquinoxaline
6-Bromoindanone
6-Bromoimidazo[1,2-a]pyridine-3-carboxylicacid
6-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE
8-BROMOQUINOLINE
4-bromoquinoline-6-carboxylic acid
4-Bromoquinoline-3-boronic acid, 97%
4-Amino-3-bromoquinoline
5-BROMO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID
2-Bromoquinoline