1,3-?????????
1,3-????????? ??
???
232-233 °C(lit.)
?? ?
408℃
??
1.02
???
1.4832 (estimate)
???
158℃
?? ??
2-8°C
???
DMSO(?? ???, ??), ???(?? ???)
??? ??
??
?? ?? (pKa)
13.89±0.20(Predicted)
??
???
???
???
InChI
InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16)
InChIKey
ADFXKUOMJKEIND-UHFFFAOYSA-N
SMILES
N(C1CCCCC1)C(NC1CCCCC1)=O
CAS ??????
2387-23-7(CAS DataBase Reference)
EPA
??
?? ? ?? ??
?? ? ???? ?? (GHS)
??? ??
Xn,N
?? ???? ??
22-51/53
?????
61
WGK ??
3
TSCA
TSCA listed
HS ??
29242100
???? ???
11 - Combustible Solids
???? ??
KE-10274
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ??
?? ???? ?? - 1? ??;???? ??
?? 3
??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1,3-????????? C??? ??, ??, ??
??? ??
white crystalline powder
??
N,N''-Dicyclohexylurea,is a substituted Urea (U822500) compound, which has shown to be a potent inhibitor of juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm M. sexta. Lomustine USP Related Compound C.
?? ??
An excess of dry ice (200 g) was added gradually to a solution of dicyclohexylcarbodiimide (2.06 g, 0.01 mol), cyclohexylamine (1.98 g, 0.02 mol), and triethylamine (2.2 g, 0.02 mol) in THF at 75 ℃ over a period of 8 h. After stirring for 8 h, the reaction mixture was concentrated under reduced pressure and the resultant precipitate was collected. Fractional recrystallization of the precipitate from acetone/methanol gave N,N'-dicyclohexylurea; yield 2.2 g (98% based on dicyclohexylcarbodiimide and cyclohexylamine).
1,3-????????? ?? ?? ? ???
???
?? ??
1,3-????????? ?? ??
???( 270)?? ??
Americas 1
Australia 1
Austria 1
Belgium 3
Canada 1
China 189
Europe 3
Germany 4
India 21
Japan 4
Russia 1
Slovakia 1
Switzerland 3
Ukraine 1
United Kingdom 9
United States 27
Global 270
1,3-????????? ?? ??:
?? 1,3-?????????
Docetaxel Metabolite M4
10-Oxo Docetaxel
2-Debenzoyl-2-pentenoyl Docetaxel
(2S,4S,5R)-3-Boc-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid
Docetaxel Impurity 5
Docetaxel Impurity 36
(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
R-Erythro-taxotere
4-Dichloroethoxy-carbonyl docetaxel
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-6-yl ester, (αR,βS...
7-Epi-docetaxel (Docetaxel Impurity C)
UEXSQPKHDIPCHO-JVHVIAPCSA-N
10-Deacetylbaccatin III
Docetaxel Impurity 6
Docetaxel Impurity 37
Cabazitaxel N-2
