Almotriptan malate
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Almotriptan malate ??
- ???
- 170-172°C
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- 2-8°C
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- ??? ???(?? ???), DMSO(?? ???), ???(?? ???, ??)
- ??? ??
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- H2O: 10mg/mL, clear
- InChIKey
- QHATUKWEVNMHRY-UHFFFAOYSA-N
- SMILES
- [S](=O)(=O)(N3CCCC3)Cc1cc2c([nH]cc2CCN(C)C)cc1.OC(CC(=O)O)C(=O)O
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- ?? ? ???? ?? (GHS)
| WGK ?? | WGK 3 | ||
|---|---|---|---|
| HS ?? | 2935904000 | ||
| ???? ??? | 11 - Combustible Solids |
Almotriptan malate C??? ??, ??, ??
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Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.??? ??
Pale Yellow Solid??
Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.??
ChEBI: The malate salt of almotriptan.?? ??
Almotriptan, marketed in 2000, has the highest oralbioavailability among all triptans. It is metabolizedby both MAO-A and CYP3A4, thus has a more favorableside effects profile when compared with sumatriptan.However, it is only available in a 12.5 mg tablet form.Almotriptan malate ?? ?? ? ???
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Almotriptan malate ?? ??
???( 273)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Moxin Chemicals | +86-17320513646 +8617320513646 |
anna@molcoo.com | China | 10000 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29812 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 |
sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 |
mcbio_sales@163.com | China | 2251 | 58 |
| Shijiazhuang Gantuo Biotechnology Co., Ltd | +8613373514458 |
gantuo02@cngantuo.com | China | 203 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 28509 | 58 |
Almotriptan malate ?? ??:
AlMotriptan Related CoMpound B
{3-[2-(DiMethylaMino)ethyl]-5-[(pyrrolidine-1-yl)sulfonylMethyl]-1H-indol-1-yl}Methanol
1-[[[3-[2-(DiMethylaMino)ethyl]-1H-indol-5-yl]Methyl]sulfonyl]pyrrolidine Monohydrochloride
Enzastaurin (LY317615)
Torin 1
ABT 737
VX-661
Rapamycin
Ataluren (PTC124)
Enalapril maleate
Empagliflozin
Etretinate
Epalrestat
Almotriptan
Sumatriptan succinate
Sumatriptan
Almotriptan malate
3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide