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- Streptomyces netropsis
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- H2O: 1mg/mL
- InChIKey
- SDRHUASONSRLFR-UHFFFAOYSA-N
- SMILES
- [H]Cl.[H]Cl.NC(CCNC(C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2C)=O)=CN1C)=O)=N
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Netropsin Dihydrochloride is DNA minor groove binding ligand.Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.???????????? ?? ?? ? ???
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