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2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE

2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE ??? ???
?? ??:
433-06-7
???:
2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE
???(??):
2,2,2-TRIFLUOROETHYL 4-METHYLBENZENESULFONATE;2,2,2-trifluoroethyl ester;100532;TRIFLUORETHYLTOSYLATE;Trifluoroethyltosylate;Azithromycin Impurity 74;TRIFLUOROETHANOL TOSYLATE;2,2,2-TRIFLUOROETHYL P-TO;2,2,2-TRIFLUOROETHYL TOSYLATE;o-(p-tosyl)a,a,a,-trifluoroethanol
CBNumber:
CB2670852
???:
C9H9F3O3S
??? ??:
254.23
MOL ??:
433-06-7.mol
MSDS ??:
SDS

2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE ??

???
36-38 °C(lit.)
?? ?
87-92 °C0.1 mm Hg(lit.)
??
1 g/cm3
???
>230 °F
?? ??
Keep in dark place,Inert atmosphere,Room temperature
???
?????(???? ??), ???(???? ??)
??? ??
??
??? ??
??? ??
??
???? ?????
??
Moisture Sensitive
BRN
2699394
???
???
InChI
1S/C9H9F3O3S/c1-7-2-4-8(5-3-7)16(13,14)15-6-9(10,11)12/h2-5H,6H2,1H3
InChIKey
IGKCQDUYZULGBM-UHFFFAOYSA-N
SMILES
Cc1ccc(cc1)S(=O)(=O)OCC(F)(F)F
CAS ??????
433-06-7(CAS DataBase Reference)
NIST
Ethanol, 2,2,2-trifluoro-, 4-methylbenzenesulfonate(433-06-7)
EPA
Ethanol, 2,2,2-trifluoro-, 4-methylbenzenesulfonate (433-06-7)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26
WGK ?? 3
TSCA TSCA listed
?? ?? IRRITANT
HS ?? 29049090
???? ??? 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
2 0

2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE C??? ??, ??, ??

??? ??

WHITE CRYSTALLINE SOLID

??

2,2,2-Trifluoroethyl Tosylate is a trifluoroethylation agent used in the preparation of 2,2,2-trifluoroethyl phenyl sulfone, a potential 2,2,2-trifluoroethyl pronucleophile.

Synthesis

2,2,2-Trifluoroethyl p-Toluenesulfonate is easily prepared by treating 2,2,2-trifluoroethanol with p-Toluenesulfonyl Chloride in pyridine or in aqueous acetone containing NaOH.

2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE ?? ?? ? ???

???

?? ??


2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE ?? ??

???( 244)?? ??
??? ?? ??? ?? ?? ? ??
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2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE ?? ??:

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