??? ?????
|
|
??? ????? ??
- ???
- >280°C
- ??
- 2.435
- ???
- 0Pa at 25℃
- ?? ??
- Refrigerator
- ???
- ??? ?? ????, ????? ?? ?? ?????(96%).
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ?? ????? ?? ????
- ???
- ?? ?????(25°C?? 0.14g/100ml).
- Merck
- 14,4046
- ?? ??
- ACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3
- ???
- ??
- ??? ?? ??
- ?? ????
- ??? ?? ??
- Ferrous fumarate (141-01-5)
- InChI
- 1S/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;
- InChIKey
- PMVSDNDAUGGCCE-TYYBGVCCSA-L
- SMILES
- O=C1O[Fe]OC(=O)\C=C\1
- LogP
- 0.62
- CAS ??????
- 141-01-5(CAS DataBase Reference)
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ???? ?? | 36/37/38 | ||
|---|---|---|---|
| ????? | 22-36/37/39-24/25 | ||
| WGK ?? | 2 | ||
| RTECS ?? | LT1950000 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29171900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Aquatic Chronic 3 | ||
| ?? | LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum) | ||
| ???? ?? | KE-03969 |
??? ????? C??? ??, ??, ??
????
? (1) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(2) ??? : ? ?? 2g? 250mL ????????? ??? ? 25mL, ?? 4mL? ??? ??? ??? ??? ???? ??? ? ???? ??? ?? ???? ?? ?? ????? 3g? ??? ??? ?? ? ?? ??? ??? 5?? ??? ?? ? 75mL? ??? ????? ????? ?? 0.1N ??????????? ?? ? ?, ? ?? ??mL? 7.16mL ????? ??.
??(3) ? : ? ?? 1.0g? ?? 50mL ????? ?? 9N ?? 10mL, ? 10mL, ?????-????????? 20mL ? ???????????? 5mL? ?? 30? ?? ??? ?? ???? ?? ????. ?? ?? ??? ???? ????? ???? ??? ?? ??? ?? ?? ???? ?? ??? ? ?????? ?????? ??. ?? ????? 10mL? ??? ??? 100mL? ?? ?? 2mL? ??? ??? 50mL ????? ?? ????? ??? ???? ???? ????? ??. ???? ? ???? ??????? ?? ?????????????? ?? ??? ?, ????? ???(????)? ???? ???(????) ?? ??? ?? ??(2.0ppm ??).
?? ??????-????????? : ????? 10g ? ??????? 19.3g? ?? ?? 100mL? ??.
???????????????? : ?????????? 5g? ????????? ?? 100mL? ??.
??(4) ?? : ? ??? ?????? ?? ??? ?, ? ?? 3.0ppm ????? ??.
??(5) ??? : ? ?? 1g? 250mL ???? ??? ?? ??? 100mL? ?? ????? ???? ? ?? ??? ?? ???(? 2mL ??) ??? ???. ???? ?? ???? ??? ?? ??? 100mL? ??. ??? ?? ??? ???? ?????? 10mL? ??? ????? 2?? ??? ? ??? ????. ???? ???? ???? ???? ?? ??? ? ???? ???? ??? ?? ??? 600℃?? ??? ? ??? ?, ? ?? SO4?? 0.2% ????? ??. ? ??? 1mg? SO4 0.412mg? ????.
????
? (1) ? ?? 1.5g? ??(1→2) 25mL? ?? ??? 50mL? ?? ???? ??? ?? ??? ?????? ???? ??(3→100)?? ???? ??? ?? 105℃?? ?????. ??? ???? (2)??? ??. ????? 40mg? ? 3mL, 1N ???????? 7mL? ??? ??? ?? ??? ? ??? ?? ? ?? ?????? ??? ??? ??? ????? ??? p-?????????? 1g, ??? 10mL? ?? 2?? ?? ?? ?? ??? ????. ?????? ??(2 : 1)?? ??? 2? ???? ???? ??? ?? 2? ????. ??? ????? ????? 105℃?? ???? ??? ??? ?, ? ??? ? 152℃??.
??(2) ? (1)? ??? ????? ? ????? ??? ????.
???
? ? ?? ? 500mg? ??? ?? 500mL ??????? ?? ?? ?? (2→5) 25mL? ??? ?? ??? ???? ?? ?????????? 5.6g? ??(3→10) 50mL? ?? ??? ??? ??? ??? ??? ???? ?? 2mL? ? ?? ?? ???? ??? ???????? 8mL? ??? 5?? ??? ? ? 200mL, ??(1→2) 25mL, ?? 4mL? ???? o-???????? ??? 0.1N ?????????? ????.
0.1N ???????? 1mL ＝ 16.99mg C4H2FeO4
??
Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.??? ??
Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.??
Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency. Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.??
Ferrous fumarate is a dicarboxylic acid. Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubility. It is used in treatment of iron deficiency anemia.?? ??
Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant.Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID.?? ??
Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.??? ????? ?? ?? ? ???
???
?? ??
??? ????? ?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| DONBOO AMINO ACID COMPANY | 13063595538 |
donboo@donboo.com | China | 9363 | 58 |
| Aurora Industry Co., Ltd. | +86-13591747876 |
alex1_auco@126.com | China | 300 | 58 |
| Jiangsu Scyence Industrial Co.,Ltd | 18805130257 |
sales0257@jskolod.com | China | 67 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 |
Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 |
sales1@chuanghaibio.com | China | 5218 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20120 | 58 |
| Apeloa production Co.,Limited | +86-19131931000 |
admin@apcl.com.cn | China | 861 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | 13343047651 |
admin@zlchemi.com | China | 3692 | 58 |
| Lianyungang Kaiyu Environmental Tech Co., Ltd. | +86-0086-19851820538 18052309100 |
carlos@khonorchem.com | China | 314 | 58 |