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(R)-1-Boc-3-Hydroxypiperidine

(R)-1-Boc-3-Hydroxypiperidine ??? ???
?? ??:
143900-43-0
???:
(R)-1-Boc-3-Hydroxypiperidine
???(??):
tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate;(R)-1-N-BOC-3-HYDROXYPIPERIDINE;Ibrutinib INT2;Peridine Impurity 2;(R)-1-BOC-3-PIPERIDINOL;(R)-N-BOC-3-HYDROXYPIPERIDINE;(R)-1-BOC-3-HYDROXYPIPERIDINE;(R)-1-Boc-3-hydroxypiperidine 95%;(R)-1-Boc-3-hydroxypiperidine,97%;(R)-1-Boc-3-hydroxypiperidine
CBNumber:
CB3125016
???:
C10H19NO3
??? ??:
201.26
MOL ??:
143900-43-0.mol
MSDS ??:
SDS

(R)-1-Boc-3-Hydroxypiperidine ??

???
43-50 °C
?? ?
292.3±33.0 °C(Predicted)
??
1.107±0.06 g/cm3(Predicted)
???
104°C
?? ??
2-8°C
???
???? ???
??? ??
??? ??
?? ?? (pKa)
14.74±0.20(Predicted)
??
???? ?????
?? ??
[α]/D 22±3°, c = 5 in methanol
InChI
InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey
UIJXHKXIOCDSEB-MRVPVSSYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@@H](O)C1
CAS ??????
143900-43-0(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 36/37/38-41-37/38-25
????? 26-36/37/39-45
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
?? ?? 6.1
????
HS ?? 29333990
???? ??? 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
????(GHS): Corrosion (GHS05)Skull and Crossbones (GHS06)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? P264, P270, P301+P310, P321, P330,P405, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? P280, P305+P351+P338, P310
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
NFPA 704
1
3 0

(R)-1-Boc-3-Hydroxypiperidine C??? ??, ??, ??

??? ??

White powder

??

(R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. It has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.

(R)-1-Boc-3-Hydroxypiperidine ?? ?? ? ???

???

?? ??


(R)-1-Boc-3-Hydroxypiperidine ?? ??

???( 308)?? ??
??? ?? ??? ?? ?? ? ??
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(R)-1-Boc-3-Hydroxypiperidine ?? ??:

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