????
|
|
???? ??
- ???
- 226-228°C
- ?? ?
- 595.5±60.0 °C(Predicted)
- ??
- 1.191±0.06 g/cm3(Predicted)
- ?? ??
- Keep in dark place,Sealed in dry,Room Temperature
- ???
- DMSO: 100 mg/mL (244.79 mM)
- ??? ??
- Solid
- ?? ?? (pKa)
- 10.08±0.60(Predicted)
- ??
- White to off-white
- Henry's Law Constant
- 2.0×109 mol/(m3Pa) at 25℃, HSDB (2015)
- InChI
- InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1
- InChIKey
- DRHKJLXJIQTDTD-OAHLLOKOSA-N
- SMILES
- C1(S(N)(=O)=O)=CC(C[C@H](NCCOC2=CC=CC=C2OCC)C)=CC=C1OC
- CAS ??????
- 106133-20-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ?? ??? | 106133-20-4(Hazardous Substances Data) |
|---|
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
| ??·?? ??: |
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| ??????: |
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???? C??? ??, ??, ??
??
Tamsulosin hydrochloride is the first in the class of potent and selective α- 1A adrenoceptor antagonists introduced for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). In a clinical study, significant improvement in irritative and obstructive symptoms has been reported for tamsulosin treated patients with BPH. ln vitro studies in human penile erectile tissue and vas deferens indicated that tamsulosin may be of use in treating male sexual dysfunction.??
chemotherapy drug?? ??
Tamsulosin (Flomax), a nonquinazoline benzensulfonamide,is the first in the class of subtype selective 1Ablocker.It is many folds more selective for α1A-receptorsthan for the other α1-receptors. This selectivity may favorblockade of α1A-receptors found in the prostate gland overthose found in vascular tissue. Tamsulosin is efficacious inthe treatment of BPH with little effect on blood pressure.Orthostatic hypotension is not as great with this agent aswith the nonselective quinazolines.???? ?? ?? ? ???
???
??
Palladium hydroxide
?? ???
2-(2-ethoxyphenoxy)-N-[(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide
2-(2-Ethoxyphenoxy)ethyl Methanesulfonate
5-(2-??????)-2-??????????
R-(-)-5-(2-???-???)-2-???-???????
?? ??
???? ?? ??
???( 255)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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???? ?? ??:
??? N,N-???????????? ??????????? ????????? ??????? P-???? ???? ????? ?????? ???????? ??????? ????
5-(2-Aminopropyl)-2-methoxybenzenesulfonamide
5-((2R)-2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE (INTERMEDIATE OF TAMSULOSIN)
Tamsulosin hydrochloride
Tamsulosin hydrochloride
CHEMBRDG-BB 9071974
(R)-(+)-5-(2-AMINOPROPYL)-2-METHOXYBENZENE SULFONAMIDE HYDROCHLORIDE