4-Methoxybenzylchloride is used in a synthesis of diarymethanes via Suzuki cross-coupling with postassium aryltrifluoroborates. It is also an O/N protecting group reagent which can be mildly oxidatively cleaved, e.g., with ceric ammonium nitrate.
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4-Methoxybenzyl chloride undergoes mild oxidative claevage with ceric ammonium nitrate.
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4-Methoxybenzylchloride is danger, it may be corrosive to metals. It causes severe skin burns and eye damage.
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4-Methoxybenzylchloride is danger, it may be corrosive to metals. It causes severe skin burns and eye damage.
Purification Methods
Purify 4-anisyl chloride by fractional distillation under vacuum, and the middle fraction is redistilled at 10-6 mm at room temperature by intermittent cooling of the receiver in liquid N2, and the middle fraction is collected. [Mohammed & Kosower J Am Chem Soc 93 2709 1971, Beilstein 6 IV 2137.]
