5-Bromonicotinic acid
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5-Bromonicotinic acid ??
- ???
- 178-180 °C(lit.)
- ?? ?
- 259.67°C (rough estimate)
- ??
- 1.7477 (rough estimate)
- ???
- 0.01Pa at 25℃
- ???
- 1.6120 (estimate)
- ?? ??
- 2-8°C
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 3.08±0.10(Predicted)
- ??? ??
- ??
- ??
- ??~??? ?? ?? ??
- BRN
- 115854
- InChI
- InChI=1S/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)
- InChIKey
- FQIUCPGDKPXSLL-UHFFFAOYSA-N
- SMILES
- C1=NC=C(Br)C=C1C(O)=O
- LogP
- 1.17-1.29 at 23.5℃ and pH6.4
- CAS ??????
- 20826-04-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36-24/25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | QT0868000 | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 29333999 | ||
| ???? ??? | 11 - Combustible Solids |
5-Bromonicotinic acid C??? ??, ??, ??
??? ??
Light yellow Cryst??
5-Bromopyridine-3-carboxylic acid (5-bromonicotinic acid) was used in the synthesis of 3-guanidinomethyl-5-iodopyridine.?? ??
5-Bromonicotinic acid could used as starting material to synthesize 3-guanidinomethyl-5-iodopyridine. It is also used to prepare four novel multifunctional coordination compounds with different lanthanide(III) ions (Dy, Tb, Yb, and Nd). These materials possess different structures and dimensionalities and show interesting magnetic and luminescence properties, as well as a complete absence of cytotoxicity both in cancer and non-cancer Caco-2 cells[1-2].Purification Methods
The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.]5-Bromonicotinic acid ?? ?? ? ???
???
3-Bromo-5-methylpyridine
Methyl 5-bromonicotinate
10-???-1,6-???????-8??-???
???5-??????-2,3-DICARBOXYLATE
5-Bromonicotinamide
2,4'-?????????
NICOTINYL CHLORIDE HYDROCHLORIDE
?????????
3-Bromoquinoline
3,5-Dibromopyridine
?? ??
5-Aminonicotinic acid
Methyl 5-aminopyridine-3-carboxylate
5-Fluoronicotinic acid
2-(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propan-2-ol
(5-BROMO-PYRIDIN-3-YL)-ACETONITRILE
3-BroMo-5-(???-1-?-2-?)???
3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride
3-???-1,5-?????
3-Amino-5-bromopyridine
5-Bromonicotinic acid ?? ??
???( 667)?? ??
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5-Bromonicotinic acid ?? ??:
???? ?? ?????? ?????????? ?? (8β)-10-???-1,6-???????-8-???-5-???-3-?????? ????
2,2-Dimethylbutyryl chloride
2-Phenylbutyric acid
5-Bromophthalide
5-Bromoindole
5-Bromopyrimidine
5-Bromo-2-oxindole
DIMETHYL 5-BROMOISOPHTHALATE
5-Bromonicotinic acid ethyl ester 97%,Ethyl 5-Bromonicotinic acid ethyl ester,5-BROMONICOTINIC ACID ETHYL ESTER
EPA
Xanthinol nicotinate
5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-1H-imidazolin-2-yl)nicotinic acid
Ascoric Acid