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p-????? ?????
p-????? ????? ??? ???
?? ??:
140-53-4
???:
p-????? ?????
???(??):
p-??????????
???:
4-Chlorobenzyl cyanide
???(??):
Para chloro benzyl cyanide;2-(4-Chlorophenyl)acetonitrile;(4-CHLOROPHENYL)ACETONITRILE;P-CHLOROBENZYL CYANIDE;PCCN;P-CHLOROPHENYLACETONITRILE;4-Chlorobenzeneacetonitrile;Pyrimethamine EP Impurity C;4-Chlorobenzyl cyanide/4-Chlorophenylacetonitrile;PCNN
CBNumber:
CB3390535
???:
C8H6ClN
??? ??:
151.59
MOL ??:
140-53-4.mol
MSDS ??:
SDS

p-????? ????? ??

???
25-28 °C(lit.)
?? ?
265-267 °C(lit.)
??
1.19 g/mL at 20 °C(lit.)
???
n20/D 1.543
???
>230 °F
?? ??
Sealed in dry,Room Temperature
???
0.3g/L
??? ??
?? ?? ??
??
??~???? ???
BRN
971171
?? ??
NIOSH: IDLH 25 mg/m3
InChI
1S/C8H6ClN/c9-8-3-1-7(2-4-8)5-6-10/h1-4H,5H2
InChIKey
IVYMIRMKXZAHRV-UHFFFAOYSA-N
SMILES
Clc1ccc(CC#N)cc1
CAS ??????
140-53-4(CAS DataBase Reference)
NIST
Benzeneacetonitrile, 4-chloro-(140-53-4)
EPA
Benzeneacetonitrile, 4-chloro- (140-53-4)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T,Xi
?? ???? ?? 23/24/25-36/37/38
????? 26-36/37/39-45-28B
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
RTECS ?? AL8250000
?? ?? ?? Irritant/Toxic
TSCA TSCA listed
?? ?? 6.1
???? II
HS ?? 29269095
???? ??? 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
????(GHS): Skull and Crossbones (GHS06)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H300 ??? ???? ?? ?? ?? - ?? ?? 1,2 ?? P264, P270, P301+P310, P321, P330,P405, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
3 0

p-????? ????? MSDS


4-Chlorobenzyl cyanide

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clear colorless to yellowish liquid after melting. Soluble in acetone and ethanol.

??

4-Chlorobenzyl cyanide is an intermediate for the preparation of 3-methyl-2-(4-chlorophenyl)butyric acid, which can be used to prepare pyrethroid insecticides such as fenvalerate and deltamethrin, and can be used in medicine Industrial preparation of pyrimethamine.

?? ??

4-Chlorobenzyl cyanide is obtained by the reaction of 4-Chlorobenzyl chloride with sodium cyanide. Add 4-Chlorobenzyl chloride and Benzyldodecyldimethylammonium bromide into the reaction pot, heat to 100°C, slowly add sodium cyanide aqueous solution, and react at 100-104°C for 5h (add sodium cyanide for 3h, keep warm for 2h). Then add water to dissolve sodium chloride, and separate the water layer to obtain the crude benzyl chloride cyanide, which is distilled under reduced pressure to collect 160 (2.66kPa) fractions to obtain the finished product of 4-Chlorobenzyl cyanide. The yield is above 81%.

??

ChEBI: 4-Chlorobenzyl cyanide is a nitrile that is acetonitrile in which one of the hydrogens has been replaced by a p-chlorophenyl group. It is a member of monochlorobenzenes and a nitrile. It derives from an acetonitrile.

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