Ciclesonide
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Ciclesonide ??
- ???
- 202-209C
- ?? ?
- 665.0±55.0 °C(Predicted)
- ??
- 1.23±0.1 g/cm3(Predicted)
- ?? ??
- Sealed in dry,2-8°C
- ???
- ?????(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 14.25±0.70(Predicted)
- ??? ??
- Solid
- ??
- ???? ?????
- ???? ??
- synthetic
- ???
- water: <0.1g/L
acetone: soluble
ethanol: soluble
- InChIKey
- LUKZNWIVRBCLON-GXOBDPJESA-N
- SMILES
- [C@@]12(C(=O)COC(=O)C(C)C)O[C@H](C3CCCCC3)O[C@@H]1C[C@@]1([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]21C |&1:0,11,19,21,23,33,35,37,40,r|
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| WGK ?? | WGK 3 | ||
|---|---|---|---|
| ???? ??? | 11 - Combustible Solids |
| ????(GHS): |
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| ?? ?: | Warning | ||||||||||||||
| ??·?? ??: |
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| ??????: |
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Ciclesonide C??? ??, ??, ??
??? ??
White Solid?? ??
Ciclesonide (Omnaris) is a prodrug that requireshydrolysis of the isobutyrate ester at C21 to form theactive corticosteroid (des-ciclesonide). It has minimal oralbioavailability due to extensive metabolism, mainly byCYP3A4. The metabolites of ciclesonide have not beenfully characterized.Ciclesonide ?? ?? ? ???
???
21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione
11β,16α,17α-trihydroxypregna-21-(2-methyl-1-oxopropoxy)-1,4-diene-3,20-dione
Desisobutyryl Ciclesonide
???????
Cyclohexanecarboxaldehyde
????? ?????
?????????
??????
?????????
????????
?? ??
Ciclesonide ?? ??
???( 236)?? ??
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|---|---|---|---|---|---|
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