??? ???
|
|
??? ??? ??
- ???
- -62 °C (lit.)
- ?? ?
- 180-181 °C (lit.)
- ??
- 1.156 g/mL at 25 °C (lit.)
- ?? ??
- >1 (vs air)
- ???
- 0.15 hPa (20 °C)
- ???
- n
20/D 1.413(lit.)
- ???
- 194 °F
- ?? ??
- Store below +30°C.
- ???
- ???: ?? ??
- ??? ??
- ??
- ?? ?? (pKa)
- 11.80±0.46(Predicted)
- ??
- ???
- ??
- ?? ??
- ????
- 1.3-17.4%(V)
- ???
- ??? ??
- Merck
- 14,6096
- BRN
- 774261
- Henry's Law Constant
- 3.8×101 mol/(m3Pa) at 25℃, Katrib et al. (2003)
- Dielectric constant
- 10.4（20℃）
- ???
- ????. ?? ???? ???? ????. ???.
- InChI
- 1S/C5H8O4/c1-8-4(6)3-5(7)9-2/h3H2,1-2H3
- InChIKey
- BEPAFCGSDWSTEL-UHFFFAOYSA-N
- SMILES
- COC(=O)CC(=O)OC
- LogP
- -0.05 at 20-25℃ and pH6.4
- CAS ??????
- 108-59-8(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| ????(UN No.) | NA1993 | ||
| WGK ?? | 1 | ||
| RTECS ?? | OO0950000 | ||
| ?? ?? ?? | 440 °C | ||
| ?? ?? ?? | Irritant | ||
| TSCA | TSCA listed | ||
| ?? ?? | CBL | ||
| HS ?? | 29171910 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Eye Irrit. 2 | ||
| ?? | LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg | ||
| ???? ?? | KE-24322 |
??? ??? C??? ??, ??, ??
???
???? ??? ???? ????.???
?4? ???????
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.??? ??
Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.??
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.?? ??
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
?? ??
Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.?? ??
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.??? ??? ?? ?? ? ???
???
?? ??
??????????
Methyl 3-cyclopentenecarboxylate
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER
2-Methylpyrimidine
?????????????
Primisulfuron-methyl
5-????-2-???
Pipemidic acid
5-(2-???????)-1,3-???????
3-(4-??????)?????
8-???-2-??-2H-??-3-????????
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE
5-(TETRAHYDRO-2H-THIOPYRAN-3-YL)-1,3-CYCLOHEXANEDIONE
(1-Aminocyclopropyl)methanol
1,1-Cyclopropanedicarboxylic acid dimethyl ester
?????-??
ADS
DIMETHYL BROMOMALONATE
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER
MALONICACIDDI-N-BUTYL????
3-CARBETHOXY-4-HYDROXYCOUMARIN
6-CHLORO-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID
TERT-BUTYL METHYL MALONATE
????
???????????
6-?????
5-MESITYL-1,3-????????
??? ??? ?? ??
???( 793)?? ??
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