Artemether
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Artemether ??
- ???
- 86-88°C
- ??
- D19.5 +171° (c = 2.59 in CHCl3)
- ?? ?
- 359.79°C (rough estimate)
- ??
- 1.0733 (rough estimate)
- ???
- 1.6200 (estimate)
- ?? ??
- room temp
- ???
- DMSO: ≥20mg/mL
- ??? ??
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- ?? ??
- [α]/D +155 to +175°, c = 0.5 in methanol
- Merck
- 14,815
- InChI
- InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
- InChIKey
- SXYIRMFQILZOAM-HVNFFKDJSA-N
- SMILES
- O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22 | ||
| ????? | 24/25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | KD4165000 | ||
| HS ?? | 29329930 | ||
| ???? ??? | 5.2 - Organic peroxides and self-reacting hazardous materials | ||
| Hazard Classifications | Acute Tox. 4 Oral Org. Perox. D |
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| ?? ?? ??? | 71963-77-4(Hazardous Substances Data) | ||
| ?? | LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) |
Artemether MSDS
[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
Artemether C??? ??, ??, ??
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Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.??? ??
White Solid??
Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when??
ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.?? ??
Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.Safety Profile
Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.Artemether ?? ?? ? ???
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Artemether ?? ??
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