Pentetrazol
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Pentetrazol ??
- ???
- 59-61 °C (lit.)
- ?? ?
- 194 °C/12 mmHg (lit.)
- ??
- 1.0617 (rough estimate)
- ???
- 1.4910 (estimate)
- ???
- 194°C/12mm
- ?? ??
- -20°C
- ???
- ≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 1.25±0.20(Predicted)
- ??
- ??? ??? ??
- ??
- Hygroscopic
- Merck
- 14,7141
- BRN
- 135492
- ???
- ????. ?? ???? ???? ????.
- InChI
- 1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
- InChIKey
- CWRVKFFCRWGWCS-UHFFFAOYSA-N
- SMILES
- C1CCc2nnnn2CC1
- CAS ??????
- 54-95-5(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 25-36/37/38-23/24/25 | ||
| ????? | 26-36/37/39-45 | ||
| ????(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | XF8225000 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 6.1 | ||
| ???? | II | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| ?? | LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal) |
Pentetrazol C??? ??, ??, ??
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Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.??? ??
white crystalline powder??
Non-specific CNS stimulant; convulsant; narcotic antagonist.??
ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.?? ??
White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.??? ?? ??
Dust can be explosive when suspended in air at specific concentrations. Water soluble.?? ???
Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.????
Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.???? ??
CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.Safety Profile
A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.Purification Methods
pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]Pentetrazol ?? ?? ? ???
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Pentetrazol ?? ??
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