URB597
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URB597 ??
- ?? ?
- 533.2±50.0 °C(Predicted)
- ??
- 1.23
- ?? ??
- 2-8°C
- ???
- DMSO: ~14mg/mL, ???
- ??? ??
- ??
- ?? ?? (pKa)
- 11.74±0.20(Predicted)
- ??
- ???
- ???
- ?? 3?? ?? -20°? DMSO? ??
- InChI
- 1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
- InChIKey
- ROFVXGGUISEHAM-UHFFFAOYSA-N
- SMILES
- NC(=O)c1cccc(c1)-c2cccc(OC(=O)NC3CCCCC3)c2
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | N | ||
|---|---|---|---|
| ?? ???? ?? | 50/53 | ||
| ????? | 22-24/25-60-61 | ||
| ????(UN No.) | UN 3077 9/PG 3 | ||
| WGK ?? | 3 | ||
| ???? ??? | 11 - Combustible Solids |
URB597 C??? ??, ??, ??
?? ??
URB597 binds to active sites of fatty acid amide hydrolases and inhibits their activity. URB597 alters expression of tyrosine hydroxylase and interacts with abnormal-cannabidiol (Abn-CBD) and peroxisome proliferator-activated receptors (PPARs). URB597 elicits antinociception property via cannabinoid receptor by maintaining endocannabinoid anandamide (AEA) levels. URB597 reduces abnormal hyperactivity in neurons and could be for treatment of seizures and improving synaptic plasticity.Biochem/physiol Actions
Potent, selective fatty acid amide hydrolase (FAAH) inhibitor.URB597 ?? ?? ? ???
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?? ??
URB597 ?? ??
???( 182)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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