3-Nitroacetophenone
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3-Nitroacetophenone ??
- ???
- 76-78 °C(lit.)
- ?? ?
- 202 °C(lit.)
- ??
- 1.3450 (rough estimate)
- ???
- 0.32Pa at 25℃
- ???
- 1.5468 (estimate)
- ???
- 202°C
- ?? ??
- Sealed in dry,Room Temperature
- ???
- DMSO(?? ???), ???(?? ???)
- ??? ??
- ??? ??
- ??
- ????? ???-??
- ??
- ?? ??
- ???
- 20°C?? <0.01g/100mL
- BRN
- 743002
- ???
- ????. ?? ???, ?? ??? ???? ????.
- InChI
- 1S/C8H7NO3/c1-6(10)7-3-2-4-8(5-7)9(11)12/h2-5H,1H3
- InChIKey
- ARKIFHPFTHVKDT-UHFFFAOYSA-N
- SMILES
- CC(=O)c1cccc(c1)[N+]([O-])=O
- LogP
- 1.42
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 21 | ||
| ????? | 22-24/25 | ||
| WGK ?? | 2 | ||
| RTECS ?? | AM9625000 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29147090 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Aquatic Chronic 3 | ||
| ?? ?? ??? | 121-89-1(Hazardous Substances Data) | ||
| ?? | mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD277-689, |
3-Nitroacetophenone C??? ??, ??, ??
??? ??
white to light beige crystalline powder or yellow needle-like crystals. soluble in hot water and ether, slightly soluble in ethanol. can be volatile with water vapor.??
3''-Nitroacetophenone is used as a reactant in the synthesis of fluorine based aminothiazoles with antimicrobial activity.?? ??
3-Nitroacetophenone is synthesized from acetophenone by nitration.Synthesis of 3-nitroacetophenone
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Acetophenone is carefully dissolved in concentrated sulfuric acid at 0 ℃, and mixed acid is added slowly below 0 ℃. The crude product is precipitated by quenching into ice, filtered, and washed acid free. Purification, mainly from the ortho isomer, is achieved by recrystallization from ethanol with significant lowering of the overall yield to ca. 55 %.?? ??
3-nitroacetophenone is a light beige powder. It is an anthropogenic compound which is used as a synthetic intermediate in the production of dyes and other organic compounds. (NTP, 1992)??? ?? ??
Insoluble in water.?? ???
A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.????
Flash point data for 3-Nitroacetophenone are not available, however 3-Nitroacetophenone is probably combustible.Purification Methods
Distil the ketone in steam and crystallise it from EtOH. [Beilstein 7 IV 656.]3-Nitroacetophenone ?? ?? ? ???
???
2-Nitroacetophenone
?????
3-Nitrophenylboronic acid
1-??-3-?????
??M-?????????
3-?????????
O-???????
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?? ?????????????
????(???)
?? ??
ETHYL 5-(3-NITROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE
3-ACETYLBENZONITRILE
APLPHA-BROMO-M-BENZOYLOXYACETOPHENONE
3-?????????
5-(3-NITRO-PHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
(2E)-1-(3-nitrophenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
??4-(3-?????)-2,4-?????????
3-????????
1-Propanone, 3-(dimethylamino)-1-(3-nitrophenyl)-
(2E)-1-(3-nitrophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
3-Nitroacetophenone ?? ??
???( 507)?? ??
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|---|---|---|---|---|---|
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