N6-??????????
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N6-?????????? ??
- ???
- 182 - 184°C
- ?? ?
- 675.2±65.0 °C(Predicted)
- ??
- 1.71±0.1 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- DMSO(?? ???), ???(?? ???), ???(?? ???)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 13.12±0.70(Predicted)
- ??
- ???? ?????
- ???
- ???
- InChI
- 1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1
- InChIKey
- SZBULDQSDUXAPJ-XNIJJKJLSA-N
- SMILES
- OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCCC4)ncnc23
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| WGK ?? | 3 | ||
|---|---|---|---|
| HS ?? | 29349990 | ||
| ???? ??? | 11 - Combustible Solids |
| ????(GHS): |
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| ?? ?: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| ??·?? ??: |
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| ??????: |
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N6-?????????? C??? ??, ??, ??
??
N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively). N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).??
N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.Biochem/physiol Actions
Selective A1 adenosine receptor agonist.N6-?????????? ?? ?? ? ???
???
N-cyclohexyl-7H-purin-6-amine
????,2-???-N-?????-
6-Chloropurine ribonucleoside
9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-??????
??????
???????
???
?? ??
N6-?????????? ?? ??
???( 75)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 |
sales@unisyn.cn | CHINA | 332 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 |
sales@newcanbio.com | China | 9985 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 |
info@dycnchem.com | China | 53803 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131956 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 |
info@chemlin.com.cn | China | 16101 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 9920 | 65 |
N6-?????????? ?? ??:
Tetramethylthiuram Disulfide
Vulcanization accelerator
2',3'-dideoxy-N(6)-cyclohexyladenosine
ferritin-cyclohexyladenosine
N-ALLYL-N-CYCLOHEXYLADENOSINE
N(6)-allyl-N(6)-cyclohexyladenosine
(2S)-N6-[2-ENDO-NORBORNYL]ADENOSINE
N6-METHYL-2'-DEOXY-ADENOSINE
SDZWAG994
CYCLOHEXYLADENOSINE, N6-[ADENINE-2,8-3H]-,N 6-CYCLOHEXYLADENOSINE-[2,8-3H]
6-(METHYLAMINO)PURINE
6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
6-N-HEXYLAMINOPURINE
N6-CYCLOHEXYLADENOSINE