ChemicalBook >?? ???? >??2-???-2-??????
??2-???-2-??????
|
|
??2-???-2-?????? ??
- ?? ?
- 178-182 °C (lit.)
- ??
- 1.505 g/mL at 20 °C (lit.)
- ???
- n
20/D 1.486
- ???
- 63 °C
- ?? ??
- 2-8°C
- BRN
- 1700999
- InChI
- 1S/C5H7BrO2/c1-3-4(6)5(7)8-2/h3H,1-2H3
- InChIKey
- DMKWWKUPZZAUQL-UHFFFAOYSA-N
- SMILES
- COC(=O)C(Br)=CC
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 3 | ||
| F ?????? | 8 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| ????(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ?? ?: | Warning | ||||||||||||||||||||||||||||
| ??·?? ??: |
|
||||||||||||||||||||||||||||
| ??????: |
|
??2-???-2-?????? C??? ??, ??, ??
?? ??
Methyl 2-bromo-2-butenoate(Methyl (Z)-2-bromocrotonate) yields (S)-2-bromobutanoic acid by baker′s yeast fermentation. It undergoes biotransformation catalyzed by old yellow enzyme to yield methyl (S)-2-bromobutanoate, a key intermediate for the synthesis of chiral drugs. It is a biannelating reagent which participates in double Michael-additions.Synthesis
Ethyl or methyl crotonate is treated with Br2/CCl4 or Br2/AcOH followed by dehydrobromination with quinoline or DBU to afford Methyl 2-bromo-2-butenoate.??2-???-2-?????? ?? ?? ? ???
???
?? ??
??2-???-2-?????? ?? ??
???( 29)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| Energy Chemical | 021-021-58432009 400-005-6266 |
sales8178@energy-chemical.com | China | 44816 | 61 |
| Syntechem Co.,Ltd | |
info@syntechem.com | China | 12984 | 57 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51395 | 80 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13482353728 |
sales@fdc-chemical.com | China | 9999 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; |
sales@mreda.com.cn | China | 19328 | 58 |
| Shanghai Changer Pharmaceutical Technology Co. Ltd. | 15921595598 |
qd.yu@pharmachanger.com | China | 469 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 |
3905209149@qq.com | China | 9819 | 58 |
| Zhenjiang Borun Bio-Technology Pharmaceutical Co., Ltd. | 15862994627 |
2570984291@qq.com | China | 975 | 58 |
| chemmole | 400-168-9330 15013243073 |
597760450@qq.com | China | 2942 | 58 |
??2-???-2-?????? ?? ??:
Methacrylic acid
METHYL 4-BROMOCROTONATE
Methyl 4-bromocrotonate
2(5H)-FURANONE, 3-BROMO-5-((HEXAHYDRO-1H-AZEPIN-1-YL)METHYL)-4,5-DIMET HYL-
SALOR-INT L168777-1EA
RARECHEM AL BI 0119
CEKAFIX
3-bromo-7-hydroxy-4-methyl-2H-chromen-2-one
3-BROMO-5-CARBETHOXY-4,6-DIMETHYL-2-PYRONE
METHYL 2-BROMO-2-BUTENOATE