Azetidine
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Azetidine ??
- ???
- -70°C
- ?? ?
- 61-62 °C(lit.)
- ??
- 0.847 g/mL at 25 °C(lit.)
- ???
- n
20/D 1.432(lit.)
- ???
- −5 °F
- ?? ??
- Store below +30°C.
- ?? ?? (pKa)
- 11.29(at 25℃)
- ??? ??
- ??
- ??
- ???
- ???
- ?? ??
- ??
- Moisture Sensitive/Air Sensitive
- BRN
- 102384
- Henry's Law Constant
- 4.8×100 mol/(m3Pa) at 25℃, Ebert et al. (2023)
- InChI
- 1S/C3H7N/c1-2-4-3-1/h4H,1-3H2
- InChIKey
- HONIICLYMWZJFZ-UHFFFAOYSA-N
- SMILES
- C1CNC1
- CAS ??????
- 503-29-7(CAS DataBase Reference)
- NIST
- Azetidine(503-29-7)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | F,C | ||
|---|---|---|---|
| ?? ???? ?? | 11-34 | ||
| ????? | 16-26-36/37/39-45 | ||
| ????(UN No.) | UN 2733 3/PG 2 | ||
| WGK ?? | 3 | ||
| F ?????? | 2-10 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 3.1 | ||
| ???? | I | ||
| HS ?? | 29339990 | ||
| ???? ??? | 3 - Flammable liquids | ||
| Hazard Classifications | Eye Dam. 1 Flam. Liq. 2 Skin Corr. 1B |
Azetidine C??? ??, ??, ??
??? ??
clear colorless liquid??
Azetidine is involved in a high yielding palladium-catalyzed cross-coupling reaction with aryl bromides. Further, it is used in Ullmann type coupling reaction with iodonitroflourenes. In addition to this, it reacts with bis-(3-amino-propyl)-amine to prepare N,N'-bis-(3-amino-propyl)-propanediyldiamine using palladium as a catalyst.?? ??
Phototransformations of azetidine radical cations in freonic matrices under the action of light with λ = 436nm has been investigated. The IR spectrum of azetidine in solid argon matrices has been measured.Purification Methods
Azetidine is a flammable, hygroscopic liquid smelling of ammonia, which absorbs CO2 from air and should be kept under Argon. Purify it by drying it over solid KOH and distilling it through a short Vigreux column (p 11) at atmospheric pressure (under Argon) and keeping the pot temperature below 210o. It is moisture sensitive. The hydrochloride M 93.6 has m > 300o and the hydroiodide has m 146.5o(from EtOH). The N-Me derivative has m 112o(from *C6H6/pet ether), and the Nphenylcarbamoyl derivative has m 189-190o(from EtOH). [Searles et al. J Am Chem Soc 7 8 4917 1956, Beilstein 20 H 2, 20 I 3, 20 II 3, 20 III/IV 53, 20/1 V 136.]Azetidine ?? ?? ? ???
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Azetidine ?? ??
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