ChemicalBook >?? ???? >?? ???>??? ?? ?? ???>??? ???>?? ?? ???>2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole ??? ???

?? ??:: 303727-31-3

???:: 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

???(??):: 450;L-779;CS-1697;L-779450;L-779450 (L779450);Raf Kinase Inhibitor IV;L-779450, 10 mM in DMSO;L779450, Raf kinase inhibitor;2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol;2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol

CBNumber:: CB52489583

???:: C20H14ClN3O

??? ??:: 347.8

MOL ??:: 303727-31-3.mol

MSDS ??:: SDS

?? ?? 106

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole ??

?? ?: 579.8±50.0 °C(Predicted)

??: 1.335±0.06 g/cm3(Predicted)

?? ??: Sealed in dry,2-8°C

???: DMSO:44.67(Max Conc. mg/mL);128.44(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);86.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.35(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.75(Max Conc. mM)

??? ??: ??

?? ?? (pKa): 8.09±0.10(Predicted)

??: Light yellow to yellow

InChI: 1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)

InChIKey: WXJLXRNWMLWVFB-UHFFFAOYSA-N

SMILES: ClC(C(O)=C1)=CC=C1C(N=C(C2=CC=CC=C2)N3)=C3C4=CC=NC=C4

?? ? ?? ??
?? ? ???? ?? (GHS)

WGK ??	WGK 3
HS ??	2933399990
???? ???	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H301	??? ???	?? ?? ?? - ??	?? 3	??	P264, P270, P301+P310, P321, P330,P405, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P280	????/???/???/?????? ?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.

NFPA 704

	0
2		0

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole C??? ??, ??, ??

???? ??

Potent, ATP-competitive Raf kinase inhibitor (IC 50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38 α , GSK3 β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole ?? ?? ? ???

???

?? ??

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole ?? ??

???( 106)?? ??

???	??	???	??	?? ?	??
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
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2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole ?? ??:

2-HYDROXYACETOPHENONE 3'-Hydroxyacetophenone 2'-Hydroxyacetophenone Dihydroxybenzoic acid

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