Benazepril
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Benazepril ??
- ???
- 148-149°
- ??
- D -159° (c = 1.2 in ethanol)
- ?? ?
- 691.2±55.0 °C(Predicted)
- ??
- 1.26±0.1 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- DMSO? ???
- ?? ?? (pKa)
- 3.73±0.10(Predicted)
- ??? ??
- Solid
- ??
- White to off-white
- BCS Class
- 1
- InChIKey
- XPCFTKFZXHTYIP-PMACEKPBSA-N
- SMILES
- N1(CC(O)=O)C2=CC=CC=C2CC[C@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C1=O
- CAS ??????
- 86541-75-5(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 22-24/25 | ||
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| ?? ?? ??? | 86541-75-5(Hazardous Substances Data) |
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| ?? ?: | Warning | ||||||||||||||
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Benazepril MSDS
(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid
Benazepril C??? ??, ??, ??
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ChEBI: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzy e inhibitor benazeprilat in the treatment of hypertension and heart failure.?? ???
This ACE-directed pro-drug (FWfree-acid = 424.50 g/mol; CAS 86541-75-5), also known as 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5- tetrahydro-2-oxo-(S-(R*,R*))-1H-1-benzazepine-1-acetic acid, Lotensin and CGS 14824A, is rapidly metabolized to its diacid benazeprilat (CGS 14831; FWfree-diacid = 396.44 g/mol), the latter a potent, long-acting inhibitor of peptidyl-dipeptidase A, or angiotensin I-converting enzyme, IC50 = 1.7 nM. Lotensin is used to treat hypertension, congestive heart failure, and chronic renal failure. The antihypertensive effects of benazepril begin as early as 30 min after a single dose, and those effects during consecutive dosing are also sustained for 24 h with a lesser diurnal variation in blood pressureBenazepril ?? ?? ? ???
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N-?????
Cinchonidine
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4-????????? ???
Tert-butyl ester
Benzyl 2-bromoacetate
??? ????
Ethyl 2-oxo-4-phenylbutyrate
??? ?????????????(??? ??????????)
?? ??
Benazepril ?? ??
???( 159)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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