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5-(4-??????)-5-??????

5-(4-??????)-5-??????
5-(4-??????)-5-?????? ??? ???
?? ??:
2784-27-2
???:
5-(4-??????)-5-??????
???(??):
5-(4-??????)-5-??????;5-(4-???????)-5-????????-2,4-???
???:
5-(4-HYDROXYPHENYL)-5-PHENYLHYDANTOIN
???(??):
4-hydroxyphenytoin;NSC 156081;hydroxyphenytoin;p-hydroxyphenytoin;4-Hydroxydiphenylhy;para-hydroxyphenytoin;hydroxydiphenylhydantoin;4-hydroxydiphenylhydantoin;p-hydroxydiphenylhydantoin;5--5-phenyl-d5-hydantoin-13C3
CBNumber:
CB5355815
???:
C15H12N2O3
??? ??:
268.27
MOL ??:
2784-27-2.mol
MSDS ??:
SDS

5-(4-??????)-5-?????? ??

???
>300 °C(lit.)
?? ?
411.43°C (rough estimate)
??
1.1992 (rough estimate)
???
1.5906 (estimate)
???
???50mg/mL, ??, ?? ?? ??? ???(DMF:MeOH(2:1))
??? ??
??
??? ??
??? ??
?? ?? (pKa)
8.37±0.10(Predicted)
??
???? ?????
???
36mg/L(37℃)
InChI
1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20)
InChIKey
XEEDURHPFVXALT-UHFFFAOYSA-N
SMILES
Oc1ccc(cc1)C2(NC(=O)NC2=O)c3ccccc3
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-36
WGK ?? 2
RTECS ?? MU2485000
???? ??? 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

5-(4-??????)-5-?????? C??? ??, ??, ??

??

5-(4-Hydroxyphenyl)-5-phenylhydantoin was used in enantiomeric separation of chiral pharmaceuticals using a teicoplanin chiral stationary phase by aqueous and non-aqueous packed capillary electrochromatography. It was used as internal standard in determination of phenylbutazone and its metabolite oxyphenbutazone in human plasma by GLC.

??

ChEBI: A imidazolidine-2,4-dione that consists of hydantoin bearing phenyl and 4-hydroxyphenyl substituents at position 5.

?? ??

5-(4-Hydroxyphenyl)-5-phenylhydantoin is the major metabolite of phenytoin.

5-(4-??????)-5-?????? ?? ?? ? ???

???

?? ??


5-(4-??????)-5-?????? ?? ??

???( 32)?? ??
??? ?? ??? ?? ?? ? ??
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5-(4-??????)-5-?????? ?? ??:

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