Salicylhydroxamic acid
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Salicylhydroxamic acid ??
- ???
- 177 °C (dec.) (lit.)
- ?? ?
- 276.03°C (rough estimate)
- ??
- 1.3585 (rough estimate)
- ???
- 1.5500 (estimate)
- ?? ??
- Sealed in dry,Room Temperature
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- ?? ?? (pKa)
- pK (25°) 4.19
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- Merck
- 14,8331
- BRN
- 1210520
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- InChI
- InChI=1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10)
- InChIKey
- HBROZNQEVUILML-UHFFFAOYSA-N
- SMILES
- C(NO)(=O)C1=CC=CC=C1O
- CAS ??????
- 89-73-6(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 20/21/22-36/37/38-40 | ||
| ????? | 22-26-36-24/25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | VO6870000 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29242990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Dermal Carc. 2 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Salicylhydroxamic acid C??? ??, ??, ??
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It is a white needle crystal or off-white powder with a slow-heating melting point of 168°C. It is soluble in alcohol and ether and can be sublimated. When exposed to air, it progressively turns red. It is synthesized by combining methyl salicylate and hydroxylamine hydrochloride with sodium hydroxide, followed by acidification.??
Salicylhydroxamic acid is a collector with efficient chelating effect on rare metal oxide minerals. It is used in rare metal beneficiation and has the advantages of good selectivity and strong collecting power. Salicylhydroxamic acid is mainly used as a complexing agent or extractant for rare earth ore, copper oxide ore, lead-zinc oxide ore, gold ore, kaolin, etc., as well as organic synthesis intermediates.?? ??
The synthesis of salicylhydroxamic acid involved a two-step process. In the first step, methyl salicylate was prepared by esterifying salicylic acid with methanol using 28g (0.2 mol) of salicylic acid, 81 ml of methanol, and 8 ml of concentrated sulfuric acid. In the second step, hydroxylamine was coupled with the methyl salicylate. 13.9 g (0.2mol) of hydroxylamine was mixed with 200 ml of 10% sodium hydroxide solution and cooled. To this, 152.3g (0.1mol) of methyl salicylate was added in small portions with vigorous shaking after each addition to ensure complete dissolution. The mixture was allowed to stand for 36 hours, then acidified with 2M sulphuric acid and cooled. The precipitate was filtered, recrystallized from hot water containing a drop of acetic acid, recooled, and filtered. The yield of white precipitate collected and weighed was 14g of salicylhydroxamic acid.Preparation and Characterization of Salicylhydroxamic acid and its Complexes with Iron (III), Cobalt (II) and Manganese (II)
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ChEBI: Salicylhydroxamic acid is a hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2. It has a role as an antibacterial drug, a trypanocidal drug, an EC 3.5.1.5 (urease) inhibitor and an EC 1.11.2.2 (myeloperoxidase) inhibitor. It is a member of phenols and a hydroxamic acid.Purification Methods
Crystallise the hydroxamic acid from acetic acid. [Beilstein 10 H 98.]Salicylhydroxamic acid ?? ?? ? ???
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Salicylhydroxamic acid ?? ??
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Salicylhydroxamic acid ?? ??:
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Benzohydroxamic acid
Alkyl hydroxy oximido acid
Ascoric Acid
2-(2-CHLOROETHYL)-3-HYDROXY-3,4-DIHYDRO-2H-1,3-BENZOXAZIN-4-ONE
N-METHOXY-2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZENECARBOXAMIDE
Salicylhydroxamic acid
N-HYDROXY-2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZENECARBOXAMIDE
2-(([2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOYL]AMINO)OXY)ACETIC ACID
N-[(3,4-DICHLOROBENZYL)OXY]-2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZENECARBOXAMIDE
2-(2-CHLOROETHYL)-4-OXO-3,4-DIHYDRO-2H-1,3-BENZOXAZIN-3-YL N-(4-CHLOROPHENYL)CARBAMATE
2-(2-CHLOROETHYL)-4-OXO-3,4-DIHYDRO-2H-1,3-BENZOXAZIN-3-YL N-PHENYLCARBAMATE
phosphoric acid