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???/????
???/???? ??? ???
?? ??:
465-42-9
???:
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???(??):
???/????;???/????^???????;???/???????????
???:
CAPSANTHIN
???(??):
Paprika Red;Yellow corn;CAPSANTHIN/CAPSORUBIN;E 160c;C08584;Chili Red;CAPSANTHIN;CAPSORUBINE;Capsanthine;CAPSANTHIN tlc
CBNumber:
CB5380132
???:
C40H56O3
??? ??:
584.87
MOL ??:
465-42-9.mol
MSDS ??:
SDS

???/???? ??

???
177-178℃
??
Cd +36° (chloroform)
?? ?
581.82°C (rough estimate)
??
1.012
???
1.4960 (estimate)
?? ??
-20°C
???
?????(?? ???), DMSO(?? ???), ???????(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
14.85±0.60(Predicted)
??
?? ????? ?? ?? ????
??? (Optical Rotation)
〔α〕Cd +36 (CHCl3)
?? ??(λmax)
λ: 467-471 nm Amax
Merck
14,1769
Henry's Law Constant
3.4×102 mol/(m3Pa) at 25℃, HSDB (2015)
???
???, ?? ???
??? ?? ??
COLORANT
InChIKey
VYIRVAXUEZSDNC-RDJLEWNRSA-N
SMILES
CC(/C=C/C1=C(C)C[C@@H](O)CC1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(\C=C\C([C@@]2(C)C(C)(C)C[C@H](O)C2)=O)C
LogP
9.467 (est)

??

WGK ?? 3
HS ?? 2914.50.3000
???? ??? 11 - Combustible Solids
?? ?? ??? 465-42-9(Hazardous Substances Data)

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Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities. It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells. Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis. It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; ).

??

Capsanthin may be used as an analytical reference standard for the quantification of the analyte in red pepper powder, red pepper fruits, paprika and oleoresin using chromatography techniques.

?? ??

Capsanthin, also known as the red pepper carotenoid, is one of the major color pigments of paprika oleoresin, an oil-soluble extract, isolated from the fruits of Capsicum annum Linn or Capsicum frutescens. It is widely used as a color additive in food industries across the globe. The photoprotective effect of capsanthin protects human dermal fibroblasts against UVB induced DNA damage.

???

A poison by skin contact.

Safety Profile

A poison by skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.

Purification Methods

Possible impurities are zeaxanthin and capsorubin (below). Purify capsanthin by chromatography on a column of alumina (grade IV) and develop with 0.2% EtOH in *C6H6. It

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