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Sisomycin Sulfate

Sisomycin Sulfate ??? ???
?? ??:
53179-09-2
???:
Sisomycin Sulfate
???(??):
SISOMICIN SULFATE;6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4));mensiso;sisomin;Baymicin;Sisolline;pathomycin;extramycin;Sisobiotic;sisomycinsulfate
CBNumber:
CB5402393
???:
C19H39N5O11S
??? ??:
545.61
MOL ??:
53179-09-2.mol

Sisomycin Sulfate ??

???
70-73C
?? ?
155℃
???
>110°(230°F)
?? ??
Keep in dark place,Inert atmosphere,2-8°C
???
H2O: ???50mg/mL
??? ??
??
??
???? ?????
?? ??
[α]25/D 100 to 110° in water (Specific rotation (anhydrous), C=1)
???
?? ???
Merck
14,8550
???
???
?? ??
???(???)
InChIKey
JVTNJDPXUPRGIE-QNJHHENCNA-N
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T,Xi
?? ???? ?? 61-20/21/22-36/37/38
????? 53-22-36/37/39-45-36-26
WGK ?? 3
RTECS ?? WK2288000
HS ?? 2941901010
???? ??? 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Repr. 1B
?? LD50 in mice (mg/kg): 34 i.v., 221 i.p., 288 s.c. (Weinstein)
????(GHS): Exclamation Mark (GHS07)Health Hazard (GHS08)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H360 ?? ?? ????? ??? ??? ? ?? ???? ?? ?? 1A, 1B ??
??????:
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
0
2 0

Sisomycin Sulfate C??? ??, ??, ??

??

antibacterial, binds to ribosomes

Clinical Use

Although Sisomycin Sulfate has been approved for human use in theUnited States, it has not been marketed in this country. Itsantibacterial potency and effectiveness against aminoglycoside-inactivating enzymes resemble those of gentamicin.Sisomicin also exhibits pharmacokinetics and pharmacologicalproperties similar to those of gentamicin.

Safety Profile

Poison by intravenous,intramuscular, intraperitoneal, and subcutaneous routes. When heated to decomposition itemits very toxic fumes of SOx and NOx.

Sisomycin Sulfate ?? ?? ? ???

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Sisomycin Sulfate ?? ??

???( 215)?? ??
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Sisomycin Sulfate ?? ??:

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